The large-scale synthesis of ethyl 4-bromocyclohex-3-enecarboxyalate, using a mild brominating reagent derived from triphenyl phosphite and bromine, is reported. The development and comparison of both continuous and batch processes are described.
A modified addition sequence was developed based on the knowledge garnered from flow-processing, resulting in a safe and efficient process for the in situ generation of the unstable active reagent and its immediate reaction with the ketone in a batch mode process.
Development of a Safe and Robust Process for the Large-Scale Preparation of a Vinyl Bromide from a Ketone Using a (PhO)3P/Br2-Derived Reagent
http://pubs.acs.org/doi/abs/10.1021/acs.oprd.6b00100
Authors
Nachiket Likhite
Senior Research Investigator at Bristol-Myers Squibb Biocon R&D Center (BBRC)
Rajappa Vaidyanathan
Director and Head-Process Research and Development at Bristol-Myers Squibb
KIRAN SHAW…OWNER
/////Development, Safe and Robust Process, Large-Scale Preparation, Vinyl Bromide, Ketone, (PhO)3P/Br2-Derived Reagent
