1H NMR RABEPRAZOLE
RAB standard: (DMSOd6 400 MHz) δ 8.28 (d, 1H, J=5.56 Hz), 7.46 (m, 2H), 6.93 (d, 1H, J=5.68 Hz), 6.88 (m, 2H), 4.57 (AB, 2H, J=12.88 Hz), 4.10 (t, 2H, J=6.19 Hz), 3.49 (t, 2H, J=6.32 Hz), 3.25 (S, 3H), 2.17 (S, 3H), 1.98 (quin., 2H, J=6.19 Hz) 13C NMR (DMSOd6, 101 MHz) δ 162.61, 152.41, 147.95, 146.62, 121.74, 118.20, 117.32, 105.92, 68.30, 64.92, 59.64, 57.96, 28.67, 10.83.
The 1H spectrum for the RAB starting material is shown with peaks labelled and integrated. Data were collected on a 400 MHz NMR in DMSOd6, corrected to TMS by residual non-deuterated solvent.
Figure S13 COSY NMR spectrum of RAB
The COSY spectrum for the RAB starting material is shown. This was used to assign the methoxypropoxy carbon chain δ 1.98, 3.49 and 4.10. Data were collected on a 400 MHz NMR in DMSOd6, corrected to TMS by residual non-deuterated solvent.
Figure S14 HMBC spectrum of RAB
The spectrum shows the long range coupling of 1H to 13C nuclei. Coupling is observed between the 3-methyl group and the AB system, and between the various hydrogens on the alkyl chain.
