Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of elevated temperatures and pressures leads to a boost of the catalytic reaction. Hence, a major reduction in reaction time is achieved. Due to the significance as precursor for MOFs as well as high-tech and high-value polymers, the study focused on the production of 3,4,3′,4′-tetramethyl-biphenyl.
Palladium-Catalyzed Aerobic Oxidative Coupling of o-Xylene in Flow: A Safe and Scalable Protocol for Cross-Dehydrogenative Coupling
Department of Chemical Engineering and Chemistry, Micro Flow Chemistry & Process Technology, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands
Org. Process Res. Dev., Article ASAP
DOI: 10.1021/acs.oprd.6b00044
Publication Date (Web): March 10, 2016
Copyright © 2016 American Chemical Society
*E-mail: t.noel@tue.nl.
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////Palladium-Catalyzed Aerobic Oxidative Coupling, o-Xylene, Flow, Safe and Scalable Protocol, Cross-Dehydrogenative Coupling
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