Reflections on Chirality in the Pharmaceutical Industry: Past, Present and Future
Dr. Christopher J. Welch, Distinguished Scientist
Process Research & Development Merck Research Laboratories, USA
A PRESENTATION
At Chiral India 2016, New horizons in Drug development, Harnessing the power of Chirality .Organised by chemical weekly at Holiday inn international, Mumbai, India, Nov 8 2016
Christopher J. Welch
Merck Research Laboratories
Experience
Distinguished Scientist, Process & Analytical Chemistry
Merck & Co., Inc.
– Present (17 years 8 months)Rahway, NJ
Scientific Lead, Analytical Chemistry
co-chair, New Technologies Review & Licensing Committee (NT-RLC)
co-chair, Merck Research Laboratories Postdoctoral Research Fellows Committee
Previous Positions at Merck:
Science Lead, Global Analytical Chemistry 8/10 – 8/12
Distinguished Senior Investigator, Process Research 7/07 – 8/10
Associate Director. Process Research 1/06 – 6/07
Senior Research Fellow, Process Research 6/03 – 12/05
Research Fellow, Process Research 5/99 – 6/03
Director of Research
Regis Technologies
– (6 years 11 months)Morton Grove, IL (Chicago area)
– Scientific evaluation of custom organic synthesis business
– Set up contract synthesis/preparative chromatographic separation business – first of kind
Honors & Awards
Fellow
American Association for the Advancement of Science (AAAS)
Fellow
American Chemical Society (ACS)
Chirality Medal 2015
Presidential Green Chemistry Award
US Environmental Protection Agency
Industrial Advisory Board (IAB) Award
University of Nebraska Department of Chemistry
Organizations
Publications
2014 publications, part 1
Chromatographic Separation and Assignment of Absolute Configuration of Hydroxywarfarin Isomers, Chirality 26, 95-101, 2014.
Chromatographic Resolution of Closely Related Species in Pharmaceutical Chemistry: Dehalogenation Impurities and Mixtures of Halogen…more
2014 publications – part 2
Imine-based Chiroptical Sensing Approach for Analysis of Chiral Amines: From Method Design to Synthetic Application, Chem. Sci. 5, 2855-2861, 2014.
Advances in Achiral Stationary Phases for SFC, Amer. Pharm. Rev., April 2014, 36-41.
Liquid Chromatography Methods for…more
2013 Publications
Pharmaceutical Industry Practices on Genotoxic Impurities, in Pharmaceutical Industry Practices on Genotoxic Impurities, ed Heewoon Lee, Taylor & Francis, 2013.
Rapid Analysis of Residual Palladium in Pharmaceutical…more
2012
Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors, A. Bellomo, N. Celebi-Olcum, X. Bu, N. Rivera, R.T. Ruck, C.J. Welch, K.N. Houk, S.D. Dreher, Angew. Chem. Int. Ed., 51 (2012) 1-5
…more
2011 Publications
Analytical Method Volume Intensity Index:A Green Chemistry Metric for HPLC Methodology in the Pharmaceutical Industry, R. Hartman, R. Helmy, M. Al-Sayah, C. Welch, Green Chemistry 13, 934-939, 2011.
Does an Axial Propeller Shape on a…more
2010 Publications
Systematic Evaluation of New Chiral Stationary Phases for Supercritical Fluid Chromatography Using a Standard Racemate Library, Pirzada, Personick, Biba, Gong, Zhou, Schafer, Welch, J. Chromaogr.A,…more
Adsorbent Screening for Metal Impurity Removal in Pharmaceutical Process(Link)
Organic Process Research & Development
February 23, 2005
- Online Analysis of Flowing Streams Using Microflow HPLC
Organic Process Research & Development
2009
ACS Sustainable Chem. Eng. 2015, 3 (9), 1897.
P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent.
Dr. Christopher J. Welch, Distinguished Scientist, Process Research & Development, Merck Research Laboratories, USA, presentation