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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Bitter Fruit Bears Protein That Can Act Like Insulin

 diabetes  Comments Off on Bitter Fruit Bears Protein That Can Act Like Insulin
Sep 152014
 
20140911lnp2-Figure2

INSULIN LITE
Researchers identified a protein (sphere representation) that binds to and activates the insulin receptor (ribbon structure), though it’s less potent at turning on the receptor than insulin itself.
Credit: J. Agric. Food Chem

Bitter Fruit Bears Protein That Can Act Like Insulin

Diabetes: Researchers discover a protein in bitter melon that binds to and activates the insulin receptor, offering a potential path to new diabetes treatments
Practitioners of traditional medicine have long turned to a knobby green fruit known as bitter melon (Momordica charantia) to treat ailments such as diabetes. Researchers dug into the melon and discovered a protein that binds to and activates the insulin receptor, improving glucose metabolism in diabetic mice (J. Agric. Food Chem. 2014, DOI: 10.1021/jf5002099). The protein may be a starting point for the development of novel therapies for diabetes, the scientists say.
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20140911lnp2-bittermelon

THERAPEUTIC FRUIT?
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MannKind Resubmits New Drug Application to U.S. FDA for AFREZZA for the Treatment of Adults with Diabetes

 NDA  Comments Off on MannKind Resubmits New Drug Application to U.S. FDA for AFREZZA for the Treatment of Adults with Diabetes
Oct 152013
 

VALENCIA, Calif., October 14, 2013 –(BUSINESS WIRE)–MannKind Corporation (Nasdaq: MNKD) today announced the resubmission on October 13, 2013 of a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) seeking approval for the marketing and sale of AFREZZA® (insulin human [rDNA origin]) Inhalation Powder with an indication to improve glycemic control in adults with type 1 or type 2 diabetes. The resubmission is based on the entire data set from the extensive AFREZZA clinical development program and particularly the positive results from two recent Phase 3 trials, one in patients with type 1 diabetes (study 171) and one in patients with type 2 diabetes (study 175).

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