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An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

SYNTHESIS Comments Off

Dec 302014

An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

http://www.akademiai.com/content/r1t41145nn051252/?p=27bf59e482ec4093985c1e9ec3df3aba&pi=1

Flow Chemistry
Issue	Volume 1, Number 2/December 2011
Pages	56-61
DOI	10.1556/jfchem.2011.00013

Authors

Jill E. Hochlowski¹, Philip A. Searle², Noah P. Tu¹, Jeffrey Y. Pan³, Stephen G. Spanton¹, Stevan W. Djuric²

¹Structural Chemistry, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA
²Medicinal Chemistry Technologies, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA
³Automation Engineering, Advanced Technology, Global Research and Development, Abbott Laboratories 100 Abbott Park Road 60064 Abbott Park, IL USA

Abstract

We report herein a high-throughput integrated ynthesis–purification platform termed SWIFT (synthesis with integrated-flow technology) and processes that accelerate the rate at which validated small-molecule organic compounds are generated. A segmented-flow synthesizer was integrated to a preparative HPLC-MS, where each reaction product was purified immediately upon reaction completion. Further, automated structure-validation processes accelerate the rate at which drug discovery candidates are available for biological screening.

Keywords

flow synthesis, high-throughput organic synthesis, high-throughput purification, segmented flow, meso-flow

Categories

DR ANTHONY MELVIN CRASTO Ph.D amcrasto@gmail.com

MOBILE-+91 9323115463

GLENMARK SCIENTIST , NAVIMUMBAI, INDIA

……………………………………. DR ANTHONY MELVIN CRASTO Ph.D , Born in Mumbai in 1964 and graduated from Mumbai University, Completed his PhD from ICT ,1991, Mumbai, India in Organic chemistry, The thesis topic was Synthesis of Novel Pyrethroid Analogues, Currently he is working with GLENMARKPHARMA LTD, Research centre as Principal Scientist, Process Research (bulk actives) at Mahape, Navi Mumbai, India. Prior to joining Glenmark, he worked with major multinationals like Hoechst Marion Roussel, now Sanofi Aventis, & Searle India ltd, now Rpg lifesciences, etc. He has worked in Basic research, Neutraceuticals, Natural products, Flavors, Fragrances, Pheromones, Vet Drugs, Drugs, formulation, GMP etc. He has total 25 yrs exp in this field, he is now helping millions, has 9 million hits on google on all organic chemistry websites. His New Drug Approvals , Green Chemistry International, Eurekamoments in Organic Chemistry , Organic Chemistry by Dr Anthony, WIX BLOG , are some most read chemistry blogs He has hands on experience in initiation and developing novel routes for drug molecules and implementation them on commercial scale over a 29 year tenure, good knowledge of IPM, GMP, Regulatory aspects, he has several international drug patents published worldwide . He has good proficiency in Technology Transfer, Spectroscopy , Stereochemistry , Synthesis, Reactions in Org Chem , Polymorphism, Pharmaceuticals , Medicinal chemistry , Organic chemistry literature , Patent related site , Green chemistry , Reagents , R & D , Molecules , Heterocyclic chem , Sourcing etc He suffered a paralytic stroke in dec 2007 and is bound to a wheelchair, this seems to have injected feul in him to help chemists around the world, he is more active than before and is pushing boundaries, he has 2.5 lakh connections on all networking sites, He makes himself available to all, contact him on +91 9323115463, amcrasto@gmail.com