An automated flow-based synthesis of imatinib: the API of gleevec
M.D. Hopkin, I.R. Baxendale, S.V. Ley, J.C.S. Chem. Commun.2010, 46, 2450-2452.
http://pubs.rsc.org/en/Content/ArticleLanding/2010/CC/c001550d#!divAbstract
A concise, flow-based synthesis of Imatinib, a compound used for the treatment of chronic myeloid leukaemia, is described whereby all steps are conducted in tubular flow coils or cartridges packed with reagents or scavengers to effect clean product formation.
An in-linesolvent switching procedure was developed enabling the procedure to be performed with limited manual handling of intermediates.
see supp info
http://www.rsc.org/suppdata/cc/c0/c001550d/c001550d.pdf
