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Gleevec, developed by Novartis, is a tyrosine kinase inhibitor used for the treatment of chronic myeloid leukaemia and gastrointestinal stromal tumours. The drug molecule represents a particularly challenging target for flow chemistry because of the low solubility of many of the reaction components required for its synthesis. The team devised a new synthesis route that prevents the equipment blockages from product precipitation and avoids many of the labour and time intensive practices of traditional batch-based preparation.
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Malaria is a serious global health issue. Artemisinin combination treatments are the first-line drugs, but supplies are limited because artemisinin is obtained solely by extraction from Artemisia annua. A continuous-flow process that converts dihydroartemisinic acid into artemisinin (see scheme) was shown to be an inexpensive and scalable process that can ensure a steady, affordable supply of artemisinin.
Continuous-Flow Synthesis of the Anti-Malaria Drug Artemisinin†
Article first published online: 16 JAN 2012
DOI: 10.1002/anie.201107446………….http://onlinelibrary.wiley.com/doi/10.1002/anie.201107446/abstract
IMAGE………..http://phys.org/news/2013-08-chemists-fresh-approach-alloy-nanomaterials.html
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http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-9-265
IMAGE……..http://www.chemistryviews.org/details/ezine/1058453/Women_in_ChemistryA_European_Journal.html
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http://www.rsc.org/chemistryworld/2014/09/antimalarial-flow-synthesis-commercialisation-artemisinin
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http://pipeline.corante.com/archives/2014/04/
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http://pubs.rsc.org/en/content/articlelanding/2013/ob/c2ob27003j#!divAbstract
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http://onlinelibrary.wiley.com/doi/10.1002/anie.201305429/abstract
http://www.rsc.org/chemistryworld/2012/04/iron-lady
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http://www-medchem.ch.cam.ac.uk/hot_topics.php
http://www.ollusa.edu/s/1190/ollu.aspx?pgid=2674
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http://www.mdpi.com/1420-3049/19/7/9736
http://www.ed.ac.uk/alumni/services/news/news/femalechemists
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http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssummary/news_26-9-2013-11-6-53
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http://pubs.rsc.org/en/content/articlehtml/2013/ob/c3ob41464g
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http://pubs.rsc.org/en/content/articlelanding/2012/sc/c2sc21850j#!divAbstract
IMAGE……..http://evnewsreport.com/tag/battery/
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http://www.leygroup.ch.cam.ac.uk/research/continuous-flow-methodology/heterocycles-flow
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http://www.sfu.ca/chemistry/groups/britton/publications.html
IMAGE……….http://www.greentechnolog.com/green_chemistry/