1-((3-methoxyphenyl)sulfonyl)piperidine (2) is a crystalline white solid
1-((3-Methoxyphenyl)sulfonyl)piperidine: Piperidine,
1-[(3-methoxyphenyl)sulfonyl]-; (2) cas no (173681-65-7)
mp 115-116 °C;
1H NMR pdf
(400 MHz, DMSO-d6, 2.50 ppm)
δ: 1.30-1.35 (m, 2 H, N(CH2CH2)2CH2),
1.47-1.52 (m, 4 H, N(CH2CH2)2CH2),
2.85 (t, J = 5.2 Hz, 4 H, N(CH2CH2)2CH2),
3.83 (s, 3 H, OMe),
7.16 (t, J = 2.1 Hz, 1 H, Ar-H),
7.25-7.30 (m, 2 H, Ar-H),
7.55 (t, J = 8.0 Hz, 1 H, Ar-H);
13C NMR pdf
(100 MHz, DMSO-d6, 39.5 ppm)
δ: 22.8, 24.7, 46.6, 55.6, 112.3, 118.7, 119.5, 130.5, 136.7, 159.5;
IR nmax (film)/cm-1 2940, 2851, 1597, 1478, 1359, 1340, 1318, 1287, 1241, 1167, 1098, 1040, 931, 856, 724, 688; (principal peaks);
HRMS (FTMS+p-NSF) found m/z 256.1002 [M+H]+, C12H18 NO3S requires m/z 256.1002.
Reverse phase HPLC analysis reveals purity >99% (run on an Agilent Zorbax SB-C18, 5 µm, 4.6 x 150 mm column (23 °C) at a flow rate of 1.5 mL/min of 75:25 MeCN:H2O observed at 210 nm giving a retention time of 1.95 min, 1.0 mg/mL in MeCN).
