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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Mitsubishi Tanabe Pharma Corp. and Daiichi Sankyo Co. Ltd., announced that Mitsubishi Tanabe Pharma has received approval to manufacture and market the SGLT2 inhibitor, Canaglu tablets (canagliflozin hydrate) 100 mg in Japan

 japan  Comments Off on Mitsubishi Tanabe Pharma Corp. and Daiichi Sankyo Co. Ltd., announced that Mitsubishi Tanabe Pharma has received approval to manufacture and market the SGLT2 inhibitor, Canaglu tablets (canagliflozin hydrate) 100 mg in Japan
Jul 082014
 

 

 

NEWS

Diabetes Drug Receives MMA in Japan

Mitsubishi Tanabe Pharma Corp. and Daiichi Sankyo Co. Ltd., announced that Mitsubishi Tanabe Pharma has received approval to manufacture and market the SGLT2 inhibitor, Canaglu tablets (canagliflozin hydrate) 100 mg in Japan, for the treatment of patients with type 2 diabetes mellitus. Read more…

http://www.dddmag.com/news/2014/07/diabetes-drug-receives-mma-japan?et_cid=4034150&et_rid=523035093&type=headline

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GSK and Theravance announce Japanese approval for Anoro Ellipta

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Jul 082014
 
Image

GlaxoSmithKline (GSK) and Theravance have obtained approval from the Japanese Ministry of Health, Labour and Welfare for Anoro Ellipta to treat chronic obstructive pulmonary disease (COPD).

The Japanese approval for Anoro Ellipta is for the relief of various symptoms due to airway obstruction with COPDs, in the case where concurrent use of long-acting inhaled muscarinic antagonist and long-acting inhaled beta2 agonist is required

http://www.pharmaceutical-technology.com/news/newsgsk-theravance-announce-japanese-approval-anoro-ellipta-4311559?WT.mc_id=DN_News

GSK and Theravance announce Japanese approval for Anoro Ellipta
GlaxoSmithKline (GSK) and Theravance have obtained approval from the Japanese Ministry of Health, Labour and Welfare for Anoro Ellipta to treat chronic obstructive pulmonary disease (COPD).

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CHMP recommends Teva’s pregnancy prevention drug

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Jul 082014
 

 

The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending the marketing authorisation of Teva Pharmaceutical’s Seasonique for prevention of pregnancy.

Seasonique (levonorgestrel (0.15mg)/ethinyl estradiol (0.03mg) and low-dose ethinyl estradiol (0.01mg) tablets) is a 91-day extended-regimen oral contraceptive that contains a combination of female hormones that prevent ovulation.

The CHMP concluded that the benefits of Seasonique outweigh its risks and that marketing authorisation should be granted in France and in the EU member states of Austria, Belgium, Germany, Italy, Poland, Romania, Slovakia and Slovenia.

CHMP recommends Teva’s pregnancy prevention drug
The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending the marketing authorisation of Teva Pharmaceutical’s Seasonique for prevention of pregnancy.

CHMP recommends Teva’s pregnancy prevention drughttp://www.pharmaceutical-technology.com/news/newschmp-recommends-tevaspregnancy-prevention-drug-4310517

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Ethyl 3-oxohexanoate エチル=3-オキソヘキサノアテ NMR

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Jul 062014
 

 

Ethyl 3-oxohexanoate

Cas Number: 3249-68-1

Formula: C8H14O3

The Journal of Organic Chemistry, 44, p. 310, 1979 DOI: 10.1021/jo01316a039

C8H14O3
Rule 2, omit O, gives C8H14
8 – 14/2 + 1 = 2 degrees of unsaturation.
Look for 2 pi bonds or aliphatic rings, or 1 of each.

 

Structure answer

NMR answer

Even though A, B, C and D are all 2H peaks, they can be distinguished by chemical shift and splitting. B is outside the normal range for protons next to carbonyls, because it’s adjacent to both carbonyls and the combined deshielding is higher than normal.

The bands at 1745 and 1716 indicate that there are two carbonyls, probably an aliphatic ester and an aliphatic ketone. The bands at 3000-2850 indicate C-H alkane stretches.

H1 NMR Spectrum: Predict NMR spectrum

 

丁酰乙酸乙酯

ir

 

IR spectrum

 

The bands at 1745 and 1716 indicate that there are two carbonyls, probably an aliphatic ester and an aliphatic ketone. The bands at 3000-2850 indicate C-H alkane stretches.

 

 

MASS

 

丁酰乙酸乙酯

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p-Anisaldehyde, or 4-methoxybenzaldehyde. NMR

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Jul 042014
 
p-anisaldehyde, or 4-methoxybenzaldehyde.
(C8H8O2)

This 13C spectrum exhibits resonances at the following chemical shifts, and with the multiplicity indicated:

Shift (ppm)
190.8 130.2
154.6 114.5
132.0 55.4

 

55.4……….. -0CH3

114.5………TWO AROM -CH ORTHO TO O ATOM

130.2……..AROM C OF -CHO

132……….TWO AROM -CH ORTHO TO -CHO

154.6……….AROM  C OF -OGP

190.8……. CH=O GP

1H NMR

FIRST SIGNAL IS 3H OF CH3

 

SECOND IS DOUBLET OF TWO H OF AROM RING ORTHO TO O ATOM

 

THIRD IS DOUBLET OF TWO H OF AROM RING ORTHO TO -CHO GP

 

LAST IS LONE H OF CHO

IR
ANTHONY MELVIN CRASTO

THANKS AND REGARD’S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
web link
http://anthonycrasto.jimdo.com/

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Renewed focus on dementia checked by drug challenges

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Jul 042014
 

amyloid_precursor

Efforts to target amyloid protein plaques, thought to be responsible for Alzheimer’s disease, have run into trouble © Science Photo Library

The world needs to tackle head-on the market failures undermining dementia research and drug development, UK Prime Minister David Cameron told a summit of world health and finance leaders in London in June. He announced an investigation into how to get medicines to patients earlier, extend patents and facilitate research collaborations, to report this autumn. But just how much difference will these sorts of measures make when scientists are still grappling with exactly what causes different types of dementia?

Renewed focus on dementia checked by drug challenges

‘Ticking time bomb’ of global neurodegenerative disease burden will be difficult to defuse

http://www.rsc.org/chemistryworld/2014/07/asd

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Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

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Jul 032014
 

Graphical abstract: Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00643G?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-29&utm_source=toc-alert#!divAbstract

Pure β-NaYF4 nanocrystals with a hexagonal phase were synthesized in a novel way at low temperature using sparingly soluble rare-earth salts as precursors and ethanol–water as the solvent. The phase of the products could be controlled by adjusting the water content. An up-converting aqueous colloidal solution and a transparent film were obtained through a simple post-treatment.

 

Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

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*Corresponding authors
aMOE Key Laboratory of Bioinorganic and Synthetic Chemistry/State Key Laboratory of Optoelectronic Materials and Technology, Key Laboratory of Environment and Energy Chemistry of Guangdong Higher Education Institutes, School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, PR China
E-mail: ceswmm@mail.sysu.edu.cn;
Fax: +86 20 84111038
bDepartment of Chemistry, University of Toronto, 80 St George Street, Toronto, Canada M5S 3H6
E-mail: gozin@chem.utoronto.ca
CrystEngComm, 2014,16, 6526-6529

DOI: 10.1039/C4CE00643G

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Polymorphism of felodipine co-crystals with 4,4′-bipyridine

 polymorph  Comments Off on Polymorphism of felodipine co-crystals with 4,4′-bipyridine
Jul 032014
 

Graphical abstract: Polymorphism of felodipine co-crystals with 4,4′-bipyridine

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00756E?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-29&utm_source=toc-alert#!divAbstract

The calcium-channel blocking agent felodipine (Fel) forms co-crystals with 4,4′-bipyridine (BP) with 1 : 1 and 2 : 1 molar ratios. The [Fel + BP] (1 : 1) co-crystal exists in two polymorphic forms. Differential scanning calorimetry and solution calorimetry show that form I of the [Fel + BP] (1 : 1) co-crystal is the most thermodynamically stable phase. The difference in the crystal lattice energies between different polymorphs of the co-crystal is found to be comparable with that between the polymorphic forms of pure felodipine. The enthalpies of formation of the co-crystals are small, which indicates that the packing energy gain originates from only weak van der Waals interactions. Analysis of Hirshfeld surfaces of the felodipine molecule shows a similar distribution of intermolecular contacts in the co-crystals and pure felodipine.

Polymorphism of felodipine co-crystals with 4,4′-bipyridine

*Corresponding authors
aInstitution of Russian Academy of Sciences, G.A. Krestov Institute of Solution Chemistry RAS, 153045 Ivanovo, Russia
E-mail: glp@isc-ras.ru;
Fax: +7 4932 336237 ;
Tel: +7 4932 533784
bDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
CrystEngComm, 2014,16, 6603-6611

DOI: 10.1039/C4CE00756E

 

 

ANTHONY MELVIN CRASTO

THANKS AND REGARD’S
DR ANTHONY MELVIN CRASTO Ph.D

amcrasto@gmail.com

MOBILE-+91 9323115463
GLENMARK SCIENTIST ,  INDIA
web link
http://anthonycrasto.jimdo.com/

Congratulations! Your presentation titled “Anthony Crasto Glenmark scientist, helping millions with websites” has just crossed MILLION views.
アンソニー     安东尼   Энтони    안토니     أنتوني
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LinkedIn group
 
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Biotech Future Looking Rosy BIO Convention: Mood is buoyant at industry’s annual conference

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Jun 302014
 
09226-notw7-biocxd

Rosie the Riveters danced above the flight deck of the U.S.S. Midway at the BIO welcome soiree.
Credit: BIO
High above the flight deck of the U.S.S. Midway, aboard which the Biotechnology Industry Organization (BIO) hosted a welcome party for its annual convention in San Diego last Monday, “Rosie” was written large in red lights. The effect accompanied a dance routine featuring women dressed as Rosie the Riveter, but the reference to the adjective “rosy” was both overt and apropos.
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Growing High-Purity Nanotubes Nanotechnology: 92% of nanotubes generated with a new protocol have identical geometry, conductivity

 Uncategorized  Comments Off on Growing High-Purity Nanotubes Nanotechnology: 92% of nanotubes generated with a new protocol have identical geometry, conductivity
Jun 302014
 
09226-notw5-nanotubescxd

To seed the growth of highly uniform carbon nanotubes (gray), researchers use tungsten-cobalt alloy nanocrystals (yellow and orange), as shown in these side- and top-view illustrations.
Credit: Nanomaterials & Nanostructures Group/Peking
Because of their strength, flexibility, and conductivity, carbon nanotubes might one day feature prominently in devices such as solar cells and miniaturized electronic circuits. Standard methods used to grow the tiny cylinders, however, typically produce a mixture of tubes with varying carbon-atom geometries and electrical properties, making their incorporation into gadgets problematic.
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