A derivatisation agent selection guide frequently applied in analytical chemistry and related disciplines.

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Dec 032017

A derivatisation agent selection guide

Green Chem., 2017, Advance Article
DOI: 10.1039/C7GC03108D, Paper

Open Access

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence.

Marek Tobiszewski, Jacek Namiesnik, Francisco Pena-Pereira
The study reported herein is aimed at the greenness assessment of 267 derivatisation agents that are frequently applied in analytical chemistry and related disciplines.

A derivatisation agent selection guide

Marek Tobiszewski,^a Jacek Namieśnik^a and Francisco Pena-Pereira*^b

*Corresponding authors

^aDepartment of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology (GUT), 11/12 G. Narutowicza St., 80-233 Gdańsk, Poland

^bDepartment of Analytical and Food Chemistry, Faculty of Chemistry, University of Vigo, Campus As Lagoas – Marcosende s/n, 36310 Vigo, Spain
E-mail:fjpena@uvigo.es

Abstract

The study reported herein is aimed at the greenness assessment of 267 derivatisation agents that are frequently applied in analytical chemistry and related disciplines. Multicriteria decision analysis allowed obtaining three rankings of derivatisation agents applied in liquid chromatography, gas chromatography and chiral analysis. The criteria of assessment included the safety information obtained from material safety data sheets and physicochemical and environmental parameters predicted with relevant models. As for some of the agents predicted data were not available, these agents were assessed with a smaller number of criteria, within the ranking of low confidence. The results of the study will help to apply greener derivatisation agents, wherever the green chemistry principle of avoiding derivatisation cannot be fulfilled.

The present study provides an assessment, in terms of greenness, of 267 LC, GC and chiral derivatisation agents typically used in analytical chemistry and related fields. The preference rankings were performed for each group of derivatisation agents by means of MCDA according to the best relevant criteria that are available. In all three cases fine rankings were obtained for high and low confidence assumptions. For more informative assessment, it would be beneficial to include toxicological endpoints and more information about environmental persistence among assessment criteria. Incorporating valuable greenness indicators of synthesis processes such as carbon footprint or energy needs during production of each chemical as assessment criteria would be worthwhile. Unfortunately, these values are not easily available in the literature for a satisfactory number of derivatisation agents. Furthermore, recovery of derivatisation agents is another important issue that influences the greenness of derivatisation reactions, so its inclusion as assessment criterion would also be desirable. However, it is dependent on reaction specific conditions – not only the kind of derivatisation agent matters, but also analytes to be determined and solvents employed. The greenness of derivatisation agents is very rarely considered during analytical method development. The main criteria for selection of derivatisation agents are their rapidity and efficiency, but greenness should be also considered. This study allows selecting less problematic derivatisation agents for analytical method development while some clues can also be deduced for other than analytical applications.

http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC03108D?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

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Gdańsk University of Technology

Image result for Marek Tobiszewski gdansk

Marek Tobiszewski,

Department of Analytical Chemistry, Chemical Faculty, Gdańsk University of Technology (GUT), 11/12 G. Narutowicza St., 80-233 Gdańsk, Poland

Marek Tobiszewski

Gdansk University of Technolog… , Gdańsk · Department of Analytical Chemistry

Jacek Namieśnik

Gdansk University of Technolog… , Gdańsk · Department of Analytical Chemistry

Francisco Javier Pena-Pereira

PhD

PostDoc Position

University of Vigo , Vigo · Department of Analytical and Food Chemistry

Research experience

Apr 2013–present

Universidade de Vigo · Department of Analytical and Food Chemistry

Spain · Vigo
Apr 2011–Mar 2013

University of Aveiro · Centre for Environmental and Marine Studies (CESAM)

Portugal · Aveiro
Jun 2005–Apr 2011

Universidade de Vigo · Department of Analytical and Food Chemistry

Spain · Vigo

Faculty of Chemistry, University of Vigo

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Catalytic C-H amination at its limits: challenges and solutions

organic chemistry, Uncategorized Comments Off

Nov 232017

Catalytic C-H amination at its limits: challenges and solutions

Org. Chem. Front., 2017, 4,2500-2521
DOI: 10.1039/C7QO00547D, Review Article

Damien Hazelard, Pierre-Antoine Nocquet, Philippe Compain
Pushing C-H amination to its limits fosters innovative synthetic solutions and offers a deeper understanding of the reaction mechanism and scope.

Catalytic C–H amination at its limits: challenges and solutions

Damien Hazelard,^a Pierre-Antoine Nocquet^a and Philippe Compain*^a

*Corresponding authors

^aLaboratoire de Synthèse Organique et Molécules Bioactives (SYBIO), Université de Strasbourg/CNRS (UMR 7509), Ecole Européenne de Chimie, Polymères et Matériaux (ECPM), 25 rue Becquerel, 67087 Strasbourg Cedex 2, France
E-mail: philippe.compain@unistra.fr

Abstract

Catalytic C–H amination reactions enable direct functionalization of non-activated C(sp³)–H bonds with high levels of regio-, chemo- and stereoselectivity. As a powerful tool to unlock the potential of inert C–H bonds, C–H amination chemistry has been applied to the preparation of synthetically challenging targets since major simplification of synthetic sequences are expected from this approach. Pushing C–H amination to its limits has led to a deeper understanding of the reaction mechanism and scope. In this review, we present a description of the specific challenges facing catalytic C–H amination in the synthesis of natural products and related compounds, as well as innovative tactics created to overcome them. By identifying and discussing the major insights gained and strategies designed, we hope that this review will stimulate further progress in C–H amination chemistry and beyond.

Conclusion Since the seminal works of Du Bois in the early 2000s, the pace of discovery in the field of metal-catalysed C–H amination has been breath-taking. Not surprisingly, this synthetic tool has been applied to the total synthesis of many compounds of interest, given the high prevalence of the amino group in natural products and synthetic pharmaceuticals.67 Chemist’s confidence in the high potential of the C–H amination methodology to unlock inert C–H bonds has been demonstrated by its application to more and more challenging substrates. This has been a powerful drive for progress in the field. New valuable insights have been gained allowing, for example, a better regiochemical control via stereoelectronic and/or conformational effects. Innovative strategies have been discovered to direct the insertion event in substrates bearing a large degree of attendant functionality. Solutions have spanned from the elegant exploitation of kinetic isotope effects to the tactical use of protecting groups with different sizes or electronic characteristics. Systematic exploration of different catalytic systems has been also performed leading to the opening of new possibilities in C–H amination technology. Manganese-based catalysts have thus given rise to nitrenoids that overcome the low reactivity of primary aliphatic C–H bonds without interfering with weaker secondary/tertiary C–H bonds. Despite these impressive achievements, much remains to be done. Counterintuitive selectivity and unexplained reactivity should serve as a reminder that further studies are highly needed to understand in depth catalytic C–H amination chemistry. Many challenges remain on the way, from basic to applied research. A clear mechanistic view based on definitive evidence concerning the details of the C–N bond forming process would undoubtedly facilitate the rational design of efficient catalytic systems leading to higher regio-, chemio- and stereoselectivity. In particular, the quest for site-selective C–H amination through catalyst control has to be pursued.10d,e In this context, the development of efficient intermolecular C–H amination process still represents a major challenge and upcoming advancements are expected to increase the impact of this technology in organic synthesis. Future progress made in the field of catalytic C–H amination chemistry might also lead to industrial-scale applications in the next decade. It is likely that total synthesis of synthetically challenging targets related to natural products will continue to be a powerful driving force towards this goal.

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“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

amcrasto@gmail.com

Highly active, separable and recyclable bipyridine iridium catalysts for C–H borylation reactions

spectroscopy, SYNTHESIS, Uncategorized Comments Off

Nov 212017

Graphical abstract: Highly active, separable and recyclable bipyridine iridium catalysts for C–H borylation reactions

Highly active, separable and recyclable bipyridine iridium catalysts for C–H borylation reactions

Hind Mamlouk,^a Jakkrit Suriboot,^b Praveen Kumar Manyam,^a Ahmed AlYazidi,^a David E. Bergbreiter*^b and Sherzod T. Madrahimov*^a

*Corresponding authors

^aDepartment of Chemistry, Texas A&M University at Qatar, P.O. Box 23874, Doha, Qatar
E-mail: sherzod.madrahimov@qatar.tamu.edu

^bDepartment of Chemistry, Texas A&M University, College Station, USA
E-mail: bergbreiter@tamu.edu

Abstract

Iridium complexes generated from Ir(I) precursors and PIB oligomer functionalized bpy ligands efficiently catalyzed the reactions of arenes with bis(pinacolato)diboron under mild conditions to produce a variety of arylboronate compounds. The activity of this PIB bound homogeneous catalyst is similar to that of an original non-recyclable catalyst which allows it to be used under milder conditions than other reported recyclable catalysts. This oligomer-supported Ir catalyst was successfully recovered through biphasic extraction and reused for eight cycles without a loss of activity. Biphasic separation after the initial use of the catalyst led to an insignificant amount of iridium leaching from the catalyst to the product, and no iridium leaching from the catalyst was observed in the subsequent recycling runs. Arylboronate products obtained after extraction are sufficiently pure as observed by ¹H and ¹³C-NMR spectroscopy that they do not require further purification.

Hind MAMLOUK, PhD

R&D in Organic Materials Chemistry Looking for a New Challenge

3-Chloro-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)anisole (5). Transparent oil. Yield: 87%.

1H NMR (600 MHz, CDCl3) δ 7.37 (s, 1H), 7.22 – 7.16 (m, 1H), 6.99 (s, 1H), 3.82 (s, 3H), 1.34 (s, 12H);

13C NMR (101 MHz, CDCl3) δ 159.88, 134.57, 126.84, 117.71, 117.43, 84.15, 55.52, 24.82.

GCMS: RT=14.55 min, M+ = 268.1 vs MW= 268.54 g.mol-1 .

Sherzod Madrahimov

Asst. Prof.

Texas A&M University at Qa… , Doha · Science

Research experience

Aug 2015–present

Asst. Prof.

Texas A&M University at Qatar · Chemistry

Qatar · Doha
Jul 2012–Jul 2015

PostDoc Position

Northwestern University · Department of Chemistry

United States · Evanston
Aug 2007–Jul 2012

Graduate student

University of Illinois, Urbana-Champaign · Department of Chemistry

United States · Urbana

Texas A&M University at Qatar

David Bergbreiter
Professor

Contact

Department of Chemistry
Texas A&M University
College Station, TX 77843-3255

P: 979-845-3437
F: 979-845-4719
bergbreiter@chem.tamu.edu

Current Activities

Our group explores new chemistry related to catalysis and polymer functionalization using the tools and precepts of synthetic organic chemistry to prepare functional oligomers or polymers that in turn are used to either effect catalysis in a greener, more environmentally benign way or to more efficiently functionalize polymers. Often this involves creatively combining the physiochemical properties of a polymer with the reactivity of a low molecular weight compound to form new materials with new functions. These green chemistry projects involve undamental research both in synthesis and catalysis but has practical aspects because of its relevance to practical problems.

A common theme in our catalysis studies is exploring how soluble polymers can facilitate homogeneous catalysis. Homogeneous catalysts are ubiquitously used to prepare polymers, chemical intermediates, basic chemicals and pharmaceuticals. Such catalysts often use expensive or precious metals or expensive ligands or are used at relatively high catalyst loadings. The products often contain traces of these catalysts or ligands – traces that are undesirable for esthetic reasons or because of the potential toxicity of these impurities. Both the cost of these catalysts of these issues require catalyst/product separation – separations that often are inefficient and lead to chemical waste. These processes also use volatile organic solvents – solvents that have to be recovered and separated. Projects underway in our lab explore how soluble polymers can address each of these problems. Examples of past schemes that achieve this goal in a general way as highlighted in the Figure below.

We also use functional polymers to modify existing polymers. Ongoing projects involve molecular design of additives that can more efficiently modify polymers’ physical properties. We also use functional polymers in covalent layer-by-layer assembly to surface polymers’ surface chemistry. An example of this work is our use of ‘smart’ polymers that reversibly change from being water soluble cold to being insoluble and hydrophobic on heating. Such polymers’ have been used by us to prepare ‘smart’ catalysts, ‘smart’ surfaces and membranes, and to probe fundamental chemistry underlying temperature and salt-dependent protein solvation.

Jakkrit Suriboot

Research Assistant at Texas A&M University

Image result for Praveen Kumar Manyam TEXAS

Dr. Praveen Kumar

Title: Research Assistant Professor

Education: M.S., I.I.T. Roorkee
Ph.D., Panjab University Chandigarh (2008)
Visiting Fellow (w/ Prof. G. G. Balint-Kurti), Bristol University, UK
Postdoctoral Research Associate (w/ Prof. Svetlana Malinovskaya), Stevens Institute of Technology, Hoboken, NJ
Senior Postdoctoral Research Associate (w/ Prof. Seogjoo Jang), Queens College of CUNY, NY

Office: Chemistry 010

Phone: 806-742-3124

Email: praveen.kumar@ttu.edu

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“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

amcrasto@gmail.com

Biovis PSA2000 Automated Particle Size Analysis System (The 21 CFR Part 11 compliance module )

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Nov 122017

Inline images 1

Biovis PSA2000

Automated Particle Size Analysis System

Biovis PSA 2000 system designed to provide particle size and shape analysis with more than 70 measurements on size shape and color makes it a unique solution for R&D and QC applications in Pharmaceutical, Food processing, Paint , Ink Coating and many other applications. The 21 CFR Part 11 compliance module make it more preferred for the Manufacturing plants working under USFDA guidelines. Report available on request, or download link available below, it is as per the regulatory requirements.

For R&D the non FDA version of the software can provide huge amount of data which can be mined to help find more information about the particulate matter based on its size and shape thereby improve the Drug delivery, Process Engineering , process development etc…

Biovis PSA2000 is an automated particle size analysis system for comprehensive investigation of different types of dry or wet particulate matter such as fibres, emulsions, crystals, powders, spray droplets, or suspensions, etc.

– Rapid automated analysis of thousands of individual particles

– Detect particles as small as 0.5 micron

– Compliance to FDA 21 CFR Part 11 standards

– Custom built analysis routines to handle specific sample types

– Detect and classify particle types on the basis of size, shape, color

– Professional Analysis Report generation

The Biovis PSA 2000 system with Biovis Particle Plus Ver 5.3 has the following features

Reports with D10, D50, D90 values.
Number and Volume distribution charts
Administrator driven Login Policies.
Powerful macros/methods for automatic detection of different types of samples to achieve repeatable results with different users for same samples.
Micro Image documentation with Electronic Signature as per 21 CFR Part II compliance guidelines.
Complete audit trail to trace every action in each experiment.

Departments that can benefit from Biovis PSA 2000 system are

Process development/ Process Engineering
Quality Control ( Finished Material/ Inward Raw Material)
Performance of finished product ( Aspect ratio /roundness factor helps better design of final product)
Research and Development

For more information please go through the weblink http://www.expertvisionlabs.com/BiovisPSA.html

Imaging Solutions

Bio-Science

BioScience application areas are turning out to be one of the leading consumers of digital imaging softwares. Quantitative analysis for images from microscopy is beneficial in Medical, Scientific and biological applications.
Image Analysis Software are used in the field of Pathology, MicroBiology, research & quality control of Medicine, Forensic sciences, etc.
Many of these fields require image processing techniques to enhance the Image before extracting relevant information from it. Characterization of minute details in the acquired image is essential in these scientific applications.

Biovis Image Plus

is perfectly suited for these applications and provides numerous functions for enhancement of Image and then obtaining morphometric, densitometry and stereological measurements.

Plant Sciences

The

Biovis PSM

– Plant Science Modules are a set of advanced solutions for a wide range of plant sciences applications. Biovis PSM is designed for Plant Pathology and Agronomy applications to provide solutions for Plant Leaf, Plant Root, Plant Seed analysis.
Whether for use in the lab, or for field level analysis, Biovis PSM is offered at different levels of flexibility and portability to the users.

Industrial Analysis

Industrial analysis requires a practical and efficient technique of studying metals and materials to understand their composition and behavior. Such Metallurgical analysis (metallography) by way of imaging softwares provides a fast and accurate method of estimating mechanical properties of materials based on their appearance. This helps to check and maintain that their product meets the required standard.
Microstructural image analysis is useful in Steel Industry, Metal Strength Analysis, manufacturing, automotive, quality control of materials, and for Metallurgist in material science applications.

Biovis Materials Plus

is aimed at providing solutions for these Material analysis requirements.

Naveen Hegde

Regards

Naveen Hegde

Expert Vision Labs

H202, Ranjit Studio,

DP Road, Dadar East,

Mumbai 400014

India.

Tel:+91 22 6637 2739 / +91 22 6637 1470

Mobile: +91 93240 51848

Fax : +91 22 6637 2739

Website : www.expertvisionlabs.com

email : nhegde@expertvisionlabs.com

Expert Vision Labs

Expert Vision Labs has pioneered Image Analysis Technology in India and has focus into developing, a flexible line of highly cost effective and quality software driven products for Research and Industrial customers in India and across the globe.
Established in 1995, Expert Vision Labs has strived to specialize in providing complete solutions for computer based imaging and vision related applications. Have developed the

Biovis

image analysis product line for diverse applications in genetics, bioscience, material science and industrial applications.

Report available on request, or download here is as per the regulatory requirements.
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“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

amcrasto@gmail.com

Synthesis with Catalysts

Uncategorized Comments Off

Nov 112017

Axay Parmar

Founder at Synthesis with Catalysts Pvt. Ltd

axayrp@gmail.com

+91- 999-997-2051

info@synthesiswithcatalysts.com

Synthesis with Catalysts Pt. Ltd. is a company started with an aim to produce chiral and achiral precious metal based catalysts on commercial scale in line with “Clean and Green India” and “Make in India” vision of Government of India. These catalysts have been developed to promote efficient, economical and environmentally benign processes for the target compounds being produced in aroma, fine chemicals and pharmaceutical industries. These catalysts and their intermediates are also extensively used in academic and industrial R&D centres across globe. In India these catalysts are currently imported at a very prohibitive cost, due to which their use is limited for want of funds. In this direction Synthesis with Catalysts Pvt. Ltd. is striving to make these products available to indigenously available at a very competitive price at small and bulk scale. We are also doing in-house research to optimize process parameters ofvarious organic transformations particularly asymmetric hydrogenation and isomerization reactionsfor customers as and when required.

For the list of our products please visit our wesitewww.synthesiswithcatalysts.com

ABOUT US

Our vision is to be the most respected catalyst manufacturing company in the country
Our goal is to help our customers:
to further improve their production methodologies

increase productivity,
develop new products with the intervention of catalysts to make the process green and clean

Highly selective catalysts for intended application
Competitive pricing with short delivery lead times
Custom product and process development

Activities:A

Manufacture of Homogeneous catalysts using metal ions viz. Rh, Pt, Ir, Pd, Ru, Co, and Mn

Manufacture of ligands and intermediates

Pharmaceutical, bulk drugs, API, aroma chemical, essential oil industries served

Focus on chiral chemistries

Gram to kilogram quantities

ASYMMETR

Some of the representative reactions are:

ASYMMETRIC/ CHEMOSELECTIVE HYDROGENATION CATALYSTS

Statements

Catalysts are chiral metal complexes derived from a precious metal ion and chiral ligands
Ru used most frequently, Rh used in some cases to enhance chemo- and enantio- selectivity
Chiral ligands can be selected from variety of simple and substituted BINAP alone or in combination with chiral/achiral diamines
Suggested catalysts:
- RuCl₂[(S)-BINAP](dmf)n
- RuCl₂[(S)- tolBINAP][(S,S)-dpen]
- (S)-XylBINAP/(S)-DAIPEN-Ru
- (S)-XylBINAP/(S,S)-DPEN-Ru
- RuCl₂[(S)-tolBINAP](pica)
- RuCl[(S,S)-TsDPEN](η⁶-p-cymene)
- Ru(OTf)(TsDPEN)(p-cymene)
- BINAP-Ru(II) dicarboxylate complexes

ENANTIOSELECTIVE EPOXIDATION / HKR / DKR

Statements:

Transition metal complexes are used for chiral and non-chiral epoxidation of internal and prochiral olefins
The epoxides are important intermediates for host of industrially important products
In cases where epoxides are required in high optical purity, racemic epoxides can be subjected to Hydrolytic kinetic resolution (HKR), Aminolytic kinetic resolution (AKR), Dynamic kinetic resolutions (DKR)
Suggested catalysts:
- Mn, Co, Cr, Al complexes of chiral SALEN ligands

ASYMMETRIC ISOMERIZATION

Double bond migration reactions

Statements:

Rh-catalyzed asymmetric isomerization of allylic amines into the corresponding enamines is one of the most revered industrial organic transformation in asymmetric catalysis
It has accommodated a wide range of substrates and is a key step in the industrial production of menthol
Other industrially important isomerization is migration of terminal double bond to produce selectively trans-internal olefins
Commercially important products like isoeugenol and trans-anetheole are produced by these transformations
Suggested catalysts:
- Ru(acac)₃
- RuHCl(CO)(PPh₃)₃
- Rh/Pd complexes

Tree of popular asymmetric organic transformations

At Chiral India event in Mumbai where our technical director Dr. Abdi Is a speaker. With Basu Agarwal

Basu Agarwal

CEO at Synthesis with Catalysts Pvt Ltd

basu.ag@gmail.com

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“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

amcrasto@gmail.com

Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents

spectroscopy, SYNTHESIS, Uncategorized Comments Off

Nov 092017

Zhong-Xia WANG

N,N-dimethyl-4-biphenylamine

(1) N,N-dimethyl-[1,1′-biphenyl]-4-amine (3a) 5,6

Elute: EtOAc/petroleum ether: 1/100 (v/v), white solid, yield 97.8 mg (99%).

1H NMR (400 MHz, CDCl3): δ 7.56 (d, J = 7.8 Hz, 2H), 7.51 (d, J = 8.8 Hz, 2H), 7.40 (t, J = 7.7 Hz, 2H), 7.30–7.21 (m, 1H), 6.81 (d, J = 8.8 Hz, 2H), 3.00 (s, 6H).

13C NMR (101 MHz, CDCl3): δ 150.09, 141.34, 129.37, 128.78, 127.84, 126.43, 126.12, 112.90, 40.97.

5 Yang, X.; Wang, Z.-X. Organometallics 2014, 33, 5863.

(6) Stibingerova, I.; Voltrova, S.; Kocova, S.; Lindale, M.; Srogl, J. Org. Lett. 2016, 18, 312.

Transition-Metal-Free Cross-Coupling of Aryl and Heteroaryl Thiols with Arylzinc Reagents

Bo Yang^† and Zhong-Xia Wang^*^†^‡

^† CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Sciences at Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China

^‡ Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, P. R. China

Org. Lett., Article ASAP

DOI: 10.1021/acs.orglett.7b03145

*E-mail: zxwang@ustc.edu.cn.

Abstract

Cross-coupling of (hetero)arylthiols with arylzinc reagents via C–S cleavage was performed under transition-metal-free conditions. The reaction displays a wide scope of substrates and high functional-group tolerance. Electron-rich and -deficient (hetero)arylthiols and arylzinc reagents can be employed in this transformation. Mg²⁺ and Li⁺ ions were demonstrated to facilitate the reaction.

In summary, we developed a transition-metal-free coupling reaction of (hetero)arylthiols with arylzinc reagents to form bi(hetero)aryls. The reaction exhibited wide substrate scope and good compatibility of functional groups. Electron-rich and -poor aryl or heteroaryl thiols can be converted. Various arylzinc reagents, including electron-rich and electron-poor reagents, can be employed as the coupling partners. Preliminary mechanistic studies suggest a nucleophilic aromatic substitution pathway, and Mg²⁺ and Li⁺ ions play important roles in the process of reaction. This study provides an example of S^2– as a leaving group in an aromatic system and an effective methodology for the synthesis of bi(hetero)aryls including pharmaceutical molecules without transition-metal impurities.

Zhong-Xia WANG


	Department：	Department of Chemistry
	Mailing Address：	Department of Chemistry, University of Science and Technology of China, 96 Jinzhai Rd, Hefei, Anhui, 230026, PR China
	Postal Code：	230026
	Phone：	+86-551-63603043
	Fax：
	Homepage：	http://chem.ustc.edu.cn/szdw_16/bd/201210/t20121023_142877.html

Zhong-Xia Wang is a professor in the Department of Chemistry at the University of Science and Technology 
of China. He received his BS degree (1983) and MS degree (1986) from Nankai University, 
and PhD degree (1997) from the University of Sussex, UK. Since July 1986, Wang has been working 
at the University of Science and Technology of China (USTC) successively as Assistant, 
Lecturer, Associate Professor, and Professor. From Aug. 1993 to Oct. 1996, he pursued his doctoral 
studies at the University of Sussex, UK, and from Oct. 1999 to Oct. 2000, he was a Research Associate 
at the Chinese University of Hong Kong.

 学 系
Department of Chemistry

Predicts

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http://pubs.acs.org/doi/10.1021/acs.orglett.7b03145

“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

Benzisoxazole: a privileged scaffold for medicinal chemistry

new drugs, organic chemistry, SYNTHESIS, Uncategorized Comments Off

Nov 082017

Benzisoxazole: a privileged scaffold for medicinal chemistry

Med. Chem. Commun., 2017, Advance Article
DOI: 10.1039/C7MD00449D, Review Article

K. P. Rakesh, C. S. Shantharam, M. B. Sridhara, H. M. Manukumar, Hua-Li Qin
The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds.

Benzisoxazole: a privileged scaffold for medicinal chemistry

K. P. Rakesh,^a C. S. Shantharam,*^b M. B. Sridhara,^c H. M. Manukumar^d and Hua-Li Qin*^a

*Corresponding authors

^aDepartment of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, PR China
E-mail:qinhuali@whut.edu.cn
Fax: +86 27 87749300

^bDepartment of Chemistry, Pooja Bhagavath Memorial Mahajana Education Centre, Mysuru-570016, India
E-mail:shantharamcs@gmail.com
Tel: +91 8904386977

^cDepartment of Chemistry, Rani Channamma University, Vidyasangama, Belagavi-591156, India

^dDepartment of Studies in Biotechnology, University of Mysore, Manasagangotri, Mysuru-570006, India

Abstract

The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number of studies on benzisoxazole-containing compounds. The unique benzisoxazole scaffold also exhibits an impressive potential as antimicrobial, anticancer, anti-inflammatory, anti-glycation agents and so on. This review examines the state of the art in medicinal chemistry as it relates to the comprehensive and general summary of the different benzisoxazole analogs, their use as starting building blocks of multifarious architectures on scales sufficient to drive human drug trials. The number of reports describing benzisoxazole-containing highly active compounds leads to the expectation that this scaffold will further emerge as a potential candidate in the field of drug discovery.

Hua-Li Qin

Dr. Hua-Li Qin Ph. D 2009
qinhuali@bu.edu

Department of Pharmaceutical Engineering, School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 205 Luoshi Road, Wuhan, PR China

Hua-Li joined the Panek group in 2005.

B.S. Chemistry Engineering 2000
M.S. Chemistry 2004 University of Science & Technology of China

C. S. Shantharam

M.Sc., Ph.D

Assistant professor

Pooja Bhagavat Memorial Mahaja… , Mysore · Department of Chemistry

Department of Chemistry, Pooja Bhagavath Memorial Mahajana Education Centre, Mysuru-570016, India

Hua-Li Qin

Manukumar H M

Master of Science

Research Scholar

University of Mysore , Mysore · Department of Biotechnology

////////////Benzisoxazole, scaffold, medicinal chemistry

“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

An efficient green protocol for the synthesis of tetra-substituted imidazoles catalyzed by zeolite BEA: effect of surface acidity and polarity of zeolite

spectroscopy, SYNTHESIS, Uncategorized Comments Off

Nov 032017

Image result for Kalpana C. Maheria sv

1-benzyl-2, 4, 5-triphenyl-1H-imidazole

. 1-Benzyl-2,4,5-triphenyl-1H-imidazole (5a, n = 1).

Off-white solid; m.p.: 160–162 °C;

anal. calcd. for C28H22N2: C, 87.01, H, 5.74, N, 7.25%. Found: C, 87.13, H, 5.70, N, 7.19%;

UV (λmax, ethanol) = 280 nm;

FT-IR (KBr, cm−1 ): 3060 (C–H stretch), 3031, 1600 (CN), 1497, 1483, 1447 (CC), 1352 (C–N stretch), 769, 697 (C–H band);

1 H NMR (400 MHz, DMSO): 5.16 (s, 2H, CH2), 6.74–7.67 (m, 20H, Ar–H) ppm;

13C NMR (100 MHz, DMSO): 47.6 (CH2, C8), 125.1 (CHarom, C28), 126.0 (CHarom, C26), 126.2 (CHarom, C30), 126.4 (CHarom, C11), 127.0 (CHarom, C15), 127.1 (CHarom, C16), 127.7 (CHarom, C20), 128.0 (CHarom, C21), 128.1 (CHarom, C25), 128.4 (CHarom, C13), 128.5 (CHarom, C18), 128.6 (CHarom, C27), 128.8 (C1), 128.8 (CHarom, C12), 128.9 (CHarom, C14), 130.1 (CHarom, C17), 130.3 (CHarom, C19), 130.5 (CHarom, C22), 130.7 (CHarom, C24), 131.0 (CHarom, C29), 134.4 (CHarom, C9), 135.1 (CHarom, C23), 136.8 (CHarom, C7), 137.0 (CHarom, C10), 137.2 (CHarom, C6), 145.4 (C2), 147.0 (C4) ppm;

MS: m/z = 387.5 (M + H)+

An efficient green protocol for the synthesis of tetra-substituted imidazoles catalyzed by zeolite BEA: effect of surface acidity and polarity of zeolite

Jenifer J. Gabla,^a Sunil R. Mistry^b and Kalpana C. Maheria*^a

Jenifer J Gabla

S V National Institute of Technology, India

Jenifer J Gabla has obtained her MSc degree in Organic Chemistry, in the year 2013 from Uka Tarsadia University, Bardoli, Gujarat. She is currently pursuing her PhD in the area of solid acid catalyzed multicomponent reactions for the synthesis of biologically active drug molecules, at Applied Chemistry Department (ACD), S. V. National Institute of Technology (SVNIT) under the guidance of Kalpana Maheria, Assistant Professor & Head, ACD, SVNIT, Surat, Gujarat, India. Her research focuses on development of novel zeolite based catalytic materials and exploring their utility in the green process development for the synthesis of medicinal compounds. She has presented her research in several national and international conferences.

Kalpana C. Maheria

*Corresponding authors

^aApplied Chemistry Department, S. V. National Institute of Technology, Ichchhanath, Surat – 395007, India
E-mail:kcmaheria@gmail.com

^bMandvi Science College, Mandvi – 394160, Surat, India

Abstract

In the present study, the catalytic activity of various medium (H-ZSM-5) and large pore (H-BEA, H-Y, H-MOR) zeolites were studied as solid acid catalysts. The zeolite H-BEA is found to be an efficient catalyst for the synthesis of 1-benzyl-2,4,5-triphenyl-1H-imidazoles through one-pot, 4-component reaction (4-CR) between benzil, NH₄OAc, substituted aromatic aldehydes and benzyl amine. The hydrophobicity, Si/Al ratio and acidic properties of zeolite BEA were well improved by controlled dealumination. The synthesized materials were characterized by various characterization techniques such as XRD, ICP-OES, BET, NH₃-TPD, FT-IR, pyridine FT-IR, ²⁷Al and ¹H MAS NMR. It has been observed that the dealumination of the parent zeolite H-BEA (12) results in the enhanced strength of Brønsted acidity up to a certain Si/Al ratio which is attributed to the inductive effect of Lewis acidic EFAl species, leading to the higher activity of the zeolite BEA (15) catalyst towards the synthesis of 1-benzyl-2,4,5-triphenyl-1H-imidazoles under thermal solvent-free conditions with good to excellent yields. Using the present catalytic synthetic protocol, diverse tetra-substituted imidazoles, which are among the significant biologically active scaffolds, were synthesized in high yield within a shorter reaction time. The effect of polarity, surface acidity and extra framework Al species of the catalysts has been well demonstrated by means of pyridine FT-IR, and ²⁷Al and ¹H MAS NMR. The solvent-free synthetic protocol makes the process environmentally benign and economically viable.

Image result for S. V. National Institute of Technology, Ichchhanath, Surat

S. V. National Institute of Technology, Ichchhanath, Surat

Mandvi Science College, Mandvi – 394160, Surat, India

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DISCLAIMER

“ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

Dimethyl carbonate: a versatile reagent for a sustainable valorization of renewables

Uncategorized Comments Off

Oct 262017

Dimethyl carbonate: a versatile reagent for a sustainable valorization of renewables

Green Chem., 2017, Advance Article
DOI: 10.1039/C7GC02118F, Critical Review

G. Fiorani, A. Perosa, M. Selva
Green upgrading of renewables via methylations and carboxymethylations with non-toxic dimethyl carbonate (DMC).

Dimethyl carbonate: a versatile reagent for a sustainable valorization of renewables

G. Fiorani,^a A. Perosa^b and M. Selva*^b

Author affiliations

*Corresponding authors

^aDepartment of Chemistry, University of Oxford, Chemistry Research Laboratory, 12 Mansfield Road, Oxford OX1 3TA, UK

^bDepartment of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Venezia Mestre, Italy
E-mail:selva@unive.it

Giulia Fiorani

Postdoctoral Research Fellow presso University of Oxford

Dr. Fiorani earned her PhD in Chemical Sciences from the University of Rome “Tor Vergata” (2010) on synthesis and applications of ionic liquids. After several post-doctoral experiences (University of Padua, Italy 2010-2012, Ca’ Foscari University of Venice 2012-2013), Giulia was awarded a Marie Curie Intra-European Fellow in 2014 at ICIQ (Institute of Chemical Research of Catalonia, Tarragona, Spain) working under the supervision of Prof. Arjan W. Kleij on the preparation of cyclic organic carbonates from CO2 and terpene based oxiranes. Giulia joined the Williams group in 2016 and is working on renewable based polymers.

Abstract

Dimethyl carbonate (DMC) is an environmentally sustainable compound which can be used efficiently for the upgrading of several promising renewables including glycerol, triglycerides, fatty acids, polysaccharides, sugar-derived platform molecules and lignin-based phenolic compounds. This review showcases a thorough overview of the main reactions where DMC acts as a methylating and/or methoxycarbonylating agent for the transformation of small bio-based molecules as well as for the synthesis of biopolymers. All processes exemplify genuine green archetypes since they couple innocuous reactants of renewable origin with non-toxic DMC. Each section of the review provides a detailed overview on reaction conditions and scope of the investigated reactions, and discusses the rationale behind the choice of catalyst(s) and the proposed mechanisms. Criticism and comments have been put forward on the pros and cons of the described methods and their perspectives, as well as on those studies which still require follow-ups and more in-depth analyses.

Giulia Fiorani

Ph. D. in Chemical Sciences

Post Doctoral Research Assistant

University of Oxford , Oxford · Department of Chemistry

Research experience

Sep 2016–present

Post Doctoral Research Assistant

University of Oxford · Department of Chemistry · Prof. Charlotte K. Williams

United Kingdom

Polymer chemistry and catalysis applied to polymers preparation.
Mar 2016–Sep 2016

Post Doctoral Research Assistant

Imperial College London · Department of Materials · Prof. Charlotte K. Williams

United Kingdom · London, England

Polymer chemistry and catalysis applied to polymers preparation.
Mar 2014–Feb 2016

Marie Curie Intra-European Fellow

ICIQ Institute of Chemical Research of Catalonia · Prof. Arjan W. Kleij

Spain

Novel applications of renewable based molecules for the preparation of cyclic carbonate and polycarbonates (FP7-PEOPLE-2013-IEF, project RENOVACARB, Grant Agreement no. 622587).
Apr 2012–Oct 2013

Post Doctoral Research Assistant

Università Ca’ Foscari Venezia · Department of Molecular Science and Nanosystems · Prof. Maurizio Selva, Prof. Alvise Benedetti

Italy

Synthesis and characterization of luminescent Ionic Liquids.
Jan 2011–Feb 2012

Post Doctoral Research Assistant

Italian National Research Council · Institute on Membrane Technology ITM · Prof. Marcella Bonchio, Dr Alberto Figoli

Italy · Rome

Project BioNexGen – development of a new generation of membrane reactors.
Jan 2010–Dec 2010

Research Assistant

University of Padova · Department of Chemical Sciences · Dr Mauro Carraro

Italy · Padova

Hybrid nanostructures organized by hybrid ligands for the preparation of new functional materials.

Teaching experience

Sep 2016–Oct 2016

Visiting Scholar

Università degli Studi di Sassari · Department of Chemistry and Pharmacy

Italy · Sassari

10 hour course on terpene chemistry for PhD students.

Education

Nov 2006–Mar 2010

University of Rome Tor Vergata

Chemical Sciences · PhD

Italy
Oct 2004–Jul 2006

University of Rome Tor Vergata

Chemistry · Master of Science

Italy
Sep 2001–Oct 2004

University of Rome Tor Vergata

Chemistry · BSc

Italy

Other

Languages

English, Italian, Spanish
Scientific Societies

Member of the Italian Chemical Society since 2007.

PEROSA Alvise

Qualifica	Professore Associato
Telefono	041 234 8958
E-mail	alvise@unive.it
Fax	041 234 8979
Web	www.unive.it/persone/alvise (scheda personale) http://venus.unive.it/alvise/
Struttura	Dipartimento di Scienze Molecolari e Nanosistemi Sito web struttura: http://www.unive.it/dsmn Sede: Campus scientifico via Torino
Research team	Environmental technology and green economy
Research team	Science of complex economic, human and natural systems
Incarichi	Delegato per il Dipartimento all’Internazionalizzazion

logo unive

Currently: Associate professor of Organic Chemistry with tenure.

Department of Molecular Sciences and Nanosystems, University Ca’ Foscari Venice.

Born in Venice in 1965. Married to Paola, two children: Alberto (2000) and Marta (2002).

Career

– 2011, was offered the senior position as Associate professor of Chemistry with Tenure at UMAss Boston.

– 2005-2014 Assistant professor of Organic Chemistry with tenure (SSD CHIM/06), University Ca’ Foscari Venice.

– 2007 Visiting scientist, University of Sydney.

– 1996-2005 Post-doctoral researcher University Ca’ Foscari Venice.

Education

– 1996 Ph.D. in Chemistry, Case Western Reserve University, Cleveland OH, USA.

– 1992 Laurea in Industrial Chemistry @ University Ca’ Foscari Venice.

Fellowships

– 2007 Endeavour Research Fellow (Austrlian Government, Department of Education, Employment and Workplace Relations) at the University of Sydney.

– 1992-1996 Fulbright Fellow (U.S. Department of State, International Educational Exchange Program) at Case Western Reserve University.

– 1993 CNR Research Fellow (1993) at Case Western Reserve University, Cleveland OH, USA.

Awards

– Ca’ Foscari Research Prize (2014, category Advanced Research).

– Royal Society of Chemistry International Journal Grants Awards (2007, 2009).

– CNR prize for research (1994).

– Outstanding teaching award CWRU (1993).

– Prize for the Laurea thesis from the Consorzio Venezia Ricerche (1992).

Editorial Board memberships

– Advisory Board of the journal “Green Chemistry” (Royal Society of Chemistry, UK).

– Editorial Advisory Board of the journal “ACS Sustainable Chemistry and Engineering” (American Chemical Society, USA).

Training and editorial activities.

– Scientific coordinator and organizer of the Summer School on Green Chemistry from 1998 to 2006 (funded by the European Commission, UNESCO, and NATO).

– Editor of the volume “Methods and Reagents for Green Chemistry” Wiley Interscience 2007.

– Editor of “Green Nanoscience”, volume 8 of the 12 volume set of the “Handbook of Green Chemistry” P. Anastas Ed., Wiley-VCH 2011.

– Author of over 60 scientific papers and chapters and of one patent in the field of organic chsmistry, with emphasis on green chemistry. Hirsch index (Scopus, Feb. 2014) = 21.

Invited talks

– Green chemistry applied to the upgrading of bio-based chemicals: towards sustainable chemical production. University of Sydney, 19 March 2014.

– Sustainable (Chemical) Solutions, Rethinking Nature in Contemporary Japan, Università Ca’ Foscari, Venezia, 25-26 February 2013

– Carbonate based ionic liquids and beyond, Green Solvents Conference, Frankfurt am Main, Dechema Gesellschaft fur Chemische Technik und Biotechnologie e. V., pp. 27, Green Solvents for Synthesis, Boppard, 8-10 Ottobre 2012

– Chemicals e Fuels da Fonti Rinnovabili, Bioforum. Biotecnologie: dove scienza e impresa si incontrano, Milano, ITER, vol. VII Edizione, Bioforum, Confindustria Venezia, 24.02.2011

– Green Chemistry for Sustainability: Teaching ionic liquids new tricks & A breath of oxygen for bio-based chemicals., Slovenian-Italian conference on Materials and Technologies for Sustainable Growth, Ajdovscina, Slovenia, 4-6 Maggio 2011

– Benign molecular design, WORKSHOP ON ECOPHARMACOVIGILANCE, Verona, 26-27 Marzo 2009

– Not merely solvents: task specific ionic liquids made by green syntheses, COIL-3 Pre-symposium workshop, Cairns, Australia, 31/05/2009

– Multiphase catalysis: a tool for green organic synthesis, Royal Australian Chemical Institute NSW Organic Chemistry Group, 28th Annual One-Day Symposium, MacQuarie University, Sydney, Australia, 5 December 2007

– Catalytic Reactions in Liquid Multiphasic Systems The acronym talk, INTAS Project on POPs, Moscow, 12-14 Giugno 2005

– Catalytic reactions in liquid multiphasic systems, Convegno: Eurogreenpol – First European Summer School on Green Chemistry of Polymers, Iasi – Rumania, 21-27 Agosto 2005

– Multiphase hydrodehalogenation reactions, RWTH Aachen – Germany, 12 Febbraio 2003

– Mechanism and Synthetic Applications of the Multiphase Catalytic Systems, International Workshop on Hazardous Halo-Aromatic Pollutants: Detoxification and Analysis, Venezia, 14-16 Maggio 2002

– The multiphase catalytic hydrodehalogenation of haloaromatics, European Summer School on Green Chemistry, Venezia, 10-15 September 2001

Academic committees

– Quality assurance board of Ca’ Foscari University

– Teaching council of the International College, Ca’ Foscari merit school.

– Academic Council of Venice International University VIU.

– Delegate for international relations of the Department of Molecular Sciences and Nanosystems.

– Scientific board of Edizioni Ca’ Foscari – Digital Publishing.

– Research committee of the Department of Molecular Sciences and Nanosystems.

– Teaching board of the Doctorate in Chemical Sciences (2012-2014).

– Teaching board of the degree course Bio- and Nanomaterials science and Technology.

– Erasmus selection committee.

– Overseas selection committee

– Post-doctoral selection committees.

Referee, reviewer, and examiner for:

– Valutazione della Qualità della Ricerca (VQR), ANVUR

– Progetti di Rilevante Interesse Nazionale (PRIN), MIUR

– American Chemical Society Petroleum Research Fund (USA).

– Ph.D. Theses, University of Nottingham (UK) and University of Sydney (Aus).

– European Science Foundation

– Journals published by: Royal Society of Chemistry, American Chemical Society, Wiley, Elsevier, Springer, IUPAC

Funded projects

– Coordinator of a Cooperlink project funded by the Italian Ministry for Education, University and Research, 2011, 12 months, entitled “Joint PhD between Università Ca’ Foscari and the University of Sydney: integration of experiment and theory towards the green synthesis of self-assemblying materials and the use of renewable resources”.

– Participant in the Project of Relevant National Interest (PRIN) “Green organic syntheses mediated by new catalytic systems”, 2010, 24 months.

– Tutor of a PhD scholarship funded by the Regione Veneto through the European Social Fund, entitled “Organic syntheses of active principles and chemicals for the pharmaceutical industry using green solvents “ 2009-2011, 36 months.

– Principal Scientist of a post-doctoral fellowship funded by the Regione Veneto through the European Social Fund entitled “New reduced environmental impact chemical synthesesfor the preparation of monomers for advanced polymers, April 2012, 12 months.

– Principal Scientist of a post-doctoral fellowship funded by the Regione Veneto through the European Social Fund entitled “Environmentally compatible chemical syntheses of fluorinated monomers for advanced materials” April 2013, 12 months.

– Principal Scientist of a post-doctoral fellowship funded by the Regione Veneto through the European Social Fund entitled “Valorisation of renewable substrates from biomass, such as glycerol and its derivatives, using green chemistry” April 2014, 12 Months

– Principal Scientist of a research contract between the chemical company Aussachem (Santandrà di Povegliano, TV), entitled: “Green Chemistry for the valorisation of glycerol and of its derivatives: new ecofriendly products” December 2013.

International collaborations and networks

– Teaching and research collaboration with the University of Sydney, School of Chemistry Laboratory for Advanced Catalysis and Sustainability prof. Thomas Maschmeyer. A joint PhD program in Chemistry was established and is currently running. Up to date 5 students (3 outgoing, 2 incoming) have benefited from this agreement The first joint PhD has been awarded in December 2013 (Marina Gottardo). Four joint publications have already been produced, and others are in preparation.

– Research collaboration with the Queen’s University of Belfast, Queen’s University Ionic Liquids Laboratory, prof. Kenneth R. Seddon, for the exchange of Erasmus students who carry out research towards their MS thesis. Currently the student Riccardo Zabeo is in Belfast w research towards his thesis, tutor dr. Perosa. Previously, the PhD student Marco Noè (tutor Perosa) spent 4 months in Belfast carrying out research that was published on an international journal.

– In the framework of a scientific collaboration with prof. Janet Scott of the Centre for Sustainable Chemical Technologies of the University of Bath, an Erasmus Mundus Joint Doctorate project entitled “Bio-Based Chemicals and Materials” was submitted in 2011 and was evaluated positively albeit not funded. Nonetheless the collaboration has already produced a joint publication.

– Summer School on Green Chemistry Network. Following the 8 editions of the “Summer school on Green Chemistry” (1998-2005) coordinated and organized by the applicant, a Green Chemistry Network was initiated that involves the following institutions: RWTH-Aachen, QUB-QUILL Belfast, UNSW-Sydney, ARKEMA-France, University of Groningen-NL, Dow Europe-CH, Universite de Poitiers, ETH-Zurich, TU-Darmstadt, Universidad Politecnica de Valencia, Delft University of Technology, TU-Munchen.

– Since 1993 Alvise Perosa is a member of the American Chemical Society.

MoU’s and International agreements

– Alvise Perosa started the Joint PhD degree in Chemistry between the University of Sydney and the Università Ca’ Foscari Venezia.

– Erasmus, Alvise Perosa is the contact person for the following Erasmus agreements: Universitat Autonoma de Barcelona, Universidad Rey Juan Carlos, Universidad Rovira i Virgili,UNIVERSITE D’AVIGNON ET DES PAYS DE VAUCLUSE, ARISTOTLE UNIVERSITY THESSALONIKI, Queen’s University of Belfast.

Academic tutoring

– Marco Noè (PhD 2009-11: 24° cycle)

– Jessica N. G. Stanley (PhD cotutelle University of Sydney, 2012-2014)

– Alessio Caretto (PhD 2012-14: 27° cycle)

– Manuela Facchin (PhD 2014-16: 29° cycle)

– Tutor if BSc and MSc level students of the degree corse in Sustainable Chemistry and Technologies and, and of the MSc degree course in Science and Technolgy of Bio- and Nanomaterials.

Teaching

– 1992-94, Case Western Reserve University, Chemistry BS: Organic Chemistry 1 Laboratory (teaching assistant award in 1993).

– 1997-2000, Università Ca’ Foscari Venezia, degree course in Environmental Sciences: Organic Chemistry Exercises.

– 1997-2000, Università Ca’ Foscari Venezia, degree course in Industrial Chemistry: Organic Chemistry 1 & 2 Laboratory, Industrial Chemistry 2 Exercises, Organic Chemistry 1 (part-time students) and Advanced Organic Chemistry.

– 2006-09, Università Ca’ Foscari Venezia, degree course in Chemical Sciences and Technologies for Cultural Heritage Conservation and Restoration: Organic Chemistry Laboratory.

– 2006-07, Università Ca’ Foscari Venezia, degree course in Chemistry, Industrial Chemistry, Materials Chemistry, Environmental Sciences: Organic Chemistry 1 and Laboratory for part-time students.

– 2005-06, 2011-12, 2012-13, 2013-14: Università Ca’ Foscari Venezia, degree course in Chemistry and in sustainable Chemical Technologies: Organic Chemistry 2 and Laboratory.

– 2011-12, Università Ca’ Foscari Venezia, degree course in Chemistry and in sustainable Chemical Technologies: Green Organic synthesis Laboratory.

– 2012-13, 2013-14 Università Ca’ Foscari Venezia, MS degree course in Bio e Nanomaterials: Colloids and Interfaces.

– 2013-14 Università Ca’ Foscari Venezia, Graduate course in Organic syntheses from renewable building blocks.

SELVA Maurizio

Qualifica	Professore Ordinario
Telefono	041 234 8687
E-mail	selva@unive.it
Fax	041 234 8979
Web	www.unive.it/persone/selva (scheda personale)
Struttura	Dipartimento di Scienze Molecolari e Nanosistemi Sito web struttura: http://www.unive.it/dsmn Sede: Campus scientifico via Torino

http://www.unive.it/data/persone/5591976/pubb_tipo

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http://pubs.rsc.org/en/Content/ArticleLanding/2017/GC/C7GC02118F?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+rss%2FGC+%28RSC+-+Green+Chem.+latest+articles%29#!divAbstract

Diethyl Isosorbide (DEI)

spectroscopy, SYNTHESIS, Uncategorized Comments Off

Oct 162017

Diethyl Isosorbide (DEI): []D 20 +95.9 (c 1, in MeOH);

1H NMR (400 MHz; CDCl3; Me4Si):  4.63 (t, J = 4.2 Hz, 1H, H-4), 4.51 (d, J = 4.1 Hz, 1H, H-3), 4.06–3.90 (m, 5H, H- 1, H-2, H-5, H-6), 3.80–3.69 (m, 1H, CH2-OC-5), 3.63–3.49 (m, 4H, H-6, CH2-OC-5, CH2- OC-2), 1.23 ppm (dt, J = 17.8, 7.0 Hz, 6H, CH3CH2O-C-2, CH3CH2O-C-5);

13C NMR (101 MHz; CDCl3; Me4Si):  86.57 (C-3), 84.45 (C-2), 80.36 (C-5), 80.27 (C-4), 73.64 (C-1), 69.81 (C-6), 66.28 (CH2-O-C-5), 65.24 (CH2-O-C-2), 15.49 ppm (CH3-CH2OC-5), 15.44 (CH3-CH2OC-2);

MS (70 eV): m/z 202 (M+ , 6%), 157 (1), 113 (17), 89 (33), 69 (100), 57 (11), 44 (39).

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