All About Drugs

Tout sur les médicaments הכל על תרופות كل شيئ عن الأدوية Все о наркотиках 关于药品的一切 డ్రగ్స్ గురించి అన్ని 마약에 관한 모든 것 Όλα για τα Ναρκωτικά Complete Tracking of Drugs Across the World by Dr Anthony Melvin Crasto, Worldpeacepeaker, worlddrugtracker, PH.D (ICT), MUMBAI, INDIA, Worlddrugtracker, Helping millions, 9 million hits on google on all websites, 2.5 lakh connections on all networks, “ALL FOR DRUGS” CATERS TO EDUCATION GLOBALLY, No commercial exploits are done or advertisements added by me. This is a compilation for educational purposes only. P.S. : The views expressed are my personal and in no-way suggest the views of the professional body or the company that I represent

GSK and Theravance announce Japanese approval for Anoro Ellipta

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Jul 082014

GlaxoSmithKline (GSK) and Theravance have obtained approval from the Japanese Ministry of Health, Labour and Welfare for Anoro Ellipta to treat chronic obstructive pulmonary disease (COPD).

The Japanese approval for Anoro Ellipta is for the relief of various symptoms due to airway obstruction with COPDs, in the case where concurrent use of long-acting inhaled muscarinic antagonist and long-acting inhaled beta2 agonist is required

http://www.pharmaceutical-technology.com/news/newsgsk-theravance-announce-japanese-approval-anoro-ellipta-4311559?WT.mc_id=DN_News

GSK and Theravance announce Japanese approval for Anoro Ellipta
GlaxoSmithKline (GSK) and Theravance have obtained approval from the Japanese Ministry of Health, Labour and Welfare for Anoro Ellipta to treat chronic obstructive pulmonary disease (COPD).

CHMP recommends Teva’s pregnancy prevention drug

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Jul 082014

The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending the marketing authorisation of Teva Pharmaceutical’s Seasonique for prevention of pregnancy.

Seasonique (levonorgestrel (0.15mg)/ethinyl estradiol (0.03mg) and low-dose ethinyl estradiol (0.01mg) tablets) is a 91-day extended-regimen oral contraceptive that contains a combination of female hormones that prevent ovulation.

The CHMP concluded that the benefits of Seasonique outweigh its risks and that marketing authorisation should be granted in France and in the EU member states of Austria, Belgium, Germany, Italy, Poland, Romania, Slovakia and Slovenia.

CHMP recommends Teva’s pregnancy prevention drug
The European Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive opinion recommending the marketing authorisation of Teva Pharmaceutical’s Seasonique for prevention of pregnancy.

CHMP recommends Teva’s pregnancy prevention drughttp://www.pharmaceutical-technology.com/news/newschmp-recommends-tevaspregnancy-prevention-drug-4310517

Ethyl 3-oxohexanoate エチル=3-オキソヘキサノアテ NMR

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Jul 062014

Ethyl 3-oxohexanoate

Cas Number: 3249-68-1

Formula: C₈H₁₄O₃

The Journal of Organic Chemistry, 44, p. 310, 1979 DOI: 10.1021/jo01316a039

C₈H₁₄O₃
Rule 2, omit O, gives C₈H₁₄
8 – 14/2 + 1 = 2 degrees of unsaturation.
Look for 2 pi bonds or aliphatic rings, or 1 of each.

Structure answer

NMR answer

Even though A, B, C and D are all 2H peaks, they can be distinguished by chemical shift and splitting. B is outside the normal range for protons next to carbonyls, because it’s adjacent to both carbonyls and the combined deshielding is higher than normal.

The bands at 1745 and 1716 indicate that there are two carbonyls, probably an aliphatic ester and an aliphatic ketone. The bands at 3000-2850 indicate C-H alkane stretches.

H1 NMR Spectrum:

Predict NMR spectrum

丁酰乙酸乙酯

IR spectrum

The bands at 1745 and 1716 indicate that there are two carbonyls, probably an aliphatic ester and an aliphatic ketone. The bands at 3000-2850 indicate C-H alkane stretches.

MASS

丁酰乙酸乙酯

p-Anisaldehyde, or 4-methoxybenzaldehyde. NMR

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Jul 042014

p-anisaldehyde, or 4-methoxybenzaldehyde.

(C₈H₈O₂)

This ¹³C spectrum exhibits resonances at the following chemical shifts, and with the multiplicity indicated:

Shift (ppm)
190.8	130.2
154.6	114.5
132.0	55.4

55.4……….. -0CH3

114.5………TWO AROM -CH ORTHO TO O ATOM

130.2……..AROM C OF -CHO

132……….TWO AROM -CH ORTHO TO -CHO

154.6……….AROM C OF -OGP

190.8……. CH=O GP

1H NMR

FIRST SIGNAL IS 3H OF CH3

SECOND IS DOUBLET OF TWO H OF AROM RING ORTHO TO O ATOM

THIRD IS DOUBLET OF TWO H OF AROM RING ORTHO TO -CHO GP

LAST IS LONE H OF CHO

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Renewed focus on dementia checked by drug challenges

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Jul 042014

Efforts to target amyloid protein plaques, thought to be responsible for Alzheimer’s disease, have run into trouble © Science Photo Library

The world needs to tackle head-on the market failures undermining dementia research and drug development, UK Prime Minister David Cameron told a summit of world health and finance leaders in London in June. He announced an investigation into how to get medicines to patients earlier, extend patents and facilitate research collaborations, to report this autumn. But just how much difference will these sorts of measures make when scientists are still grappling with exactly what causes different types of dementia?

Renewed focus on dementia checked by drug challenges

‘Ticking time bomb’ of global neurodegenerative disease burden will be difficult to defuse

http://www.rsc.org/chemistryworld/2014/07/asd

Biotech Future Looking Rosy BIO Convention: Mood is buoyant at industry’s annual conference

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Jun 302014

Rosie the Riveters danced above the flight deck of the U.S.S. Midway at the BIO welcome soiree.

Credit: BIO

High above the flight deck of the U.S.S. Midway, aboard which the Biotechnology Industry Organization (BIO) hosted a welcome party for its annual convention in San Diego last Monday, “Rosie” was written large in red lights. The effect accompanied a dance routine featuring women dressed as Rosie the Riveter, but the reference to the adjective “rosy” was both overt and apropos.

read

http://cen.acs.org/articles/92/i26/Biotech-Future-Looking-Rosy.html

Growing High-Purity Nanotubes Nanotechnology: 92% of nanotubes generated with a new protocol have identical geometry, conductivity

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Jun 302014

To seed the growth of highly uniform carbon nanotubes (gray), researchers use tungsten-cobalt alloy nanocrystals (yellow and orange), as shown in these side- and top-view illustrations.

Credit: Nanomaterials & Nanostructures Group/Peking

Because of their strength, flexibility, and conductivity, carbon nanotubes might one day feature prominently in devices such as solar cells and miniaturized electronic circuits. Standard methods used to grow the tiny cylinders, however, typically produce a mixture of tubes with varying carbon-atom geometries and electrical properties, making their incorporation into gadgets problematic.

read

http://cen.acs.org/articles/92/i26/Growing-High-Purity-Nanotubes.html