AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Technology Selection To Enhance Oral Bioavailability

 drug delivery  Comments Off on Technology Selection To Enhance Oral Bioavailability
Aug 212014
 

 

Effective technology selection for improving bioavailability (BA) can accelerate the development of promising compounds and reduce the overall cost and complexity of drug development. Science-based technology selection requires an understanding of the scientific fundamentals governing drug solubilization, absorption and metabolic fate, as well as the feasibility and performance boundaries between enabling technologies. Capsugel / Bend Research have developed a robust technology selection process facilitated by its breadth of BA-enhancing technologies and extensive experience in advancing hundreds of challenging compounds.

Published: 20-Aug-2014 | Format: PDF file  | Document type: White / Technical Paper

get it at

http://www.in-pharmatechnologist.com/smartlead/view/954647/4/Technology-Selection-To-Enhance-Oral-Bioavailability

 

 

 

 

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Microsponges: A novel strategy for drug delivery system

 drug delivery  Comments Off on Microsponges: A novel strategy for drug delivery system
Aug 102014
 

Figure 2 :Reaction vessel for microsponge preparation by liquid- liquid suspension polymerization

Microsponges are polymeric delivery systems composed of porous microspheres. They are tiny sponge-like spherical particles with a large porous surface. Moreover, they may enhance stability, reduce side effects and modify drug release favorably. Microsponge technology has many favorable characteristics, which make it a versatile drug delivery vehicle. Microsponge Systems are based on microscopic, polymer-based microspheres that can suspend or entrap a wide variety of substances, and can then be incorporated into a formulated product such as a gel, cream, liquid or powder. The outer surface is typically porous, allowing a sustained flow of substances out of the sphere. Microsponges are porous, polymeric microspheres that are used mostly for topical use and have recently been used for oral administration. Microsponges are designed to deliver a pharmaceutical active ingredient efficiently at the minimum dose and also to enhance stability, reduce side effects, and modify drug release.

http://www.japtr.org/article.asp?issn=2231-4040;year=2010;volume=1;issue=3;spage=283;epage=290;aulast=Kaity

 


Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. J Adv Pharm Technol Res 2010;1:283-90

 


Kaity S, Maiti S, Ghosh AK, Pal D, Ghosh A, Banerjee S. Microsponges: A novel strategy for drug delivery system. J Adv Pharm Technol Res [serial online] 2010 [cited 2014 Aug 10];1:283-90. Available from: http://www.japtr.org/text.asp?2010/1/3/283/72416

 

Figure 3 :Preparation of microsponges by the quasi-emulsion solvent diffusion method

 

 

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One-Two Nanopunch For Difficult-To-Treat Breast Cancer Drug Delivery: Layered nanoparticles deliver a gene silencer and a drug to shrink tumors

 cancer, drug delivery  Comments Off on One-Two Nanopunch For Difficult-To-Treat Breast Cancer Drug Delivery: Layered nanoparticles deliver a gene silencer and a drug to shrink tumors
Apr 212014
 
Illustration of layer-by-layer synthesis of nanoparticles for treating breast cancer tumors

Double Duty
To deliver a one-two nanopunch to triple-negative breast cancer tumors, researchers start with a lipid-coated sphere filled with the chemotherapy drug doxorubicin (left). Then they add alternating layers of poly-L-arginine and an siRNA sequence (center), capped off by a layer of hyaluronic acid (right), which disguises the particle from the body’s immune system.
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Women with triple-negative breast cancer, a rare but aggressive form of the disease, often find that it is difficult to treat. An early diagnosis allows more treatment options, but women with this type of cancer generally have a lower survival rate than those with other types of breast cancers. To tackle the disease, a team of researchers has developed a nanomedicine that delivers a one-two punch to tumors that weakens their defenses and obliterates them (ACS Nano 2013, DOI: 10.1021/nn4047925).
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