Synthesis, characterization and anti-inflammatory evaluation of novel substituted tetrazolodiazepine derivatives

Dr. Helen P. Kavitha

Professor and Head of the Department
E-mail: helen.p@rmp.srmuniv.ac.in
Area: Chemistry
Affiliation: Department of Chemistry, Ramapuram Campus, SRM University

Other Details:

Course

• Chemistry
• Principles of Environmental Science

Research Interests

• Organic Synthesis
• Medicinal Chemistry
• Crystal Growth
• Molecular Docking
• Nano Synthesis

Selected PublicationS

• A. Santhoshkumar, Helen P. Kavitha*, R. Suresh, Hydrothermal Synthesis, Characterization and Antibacterial Activity of NiO Nanoparticles, Journal of Advanced Chemical Sciences-Article in press
• R. Kavipriya, Helen P. Kavitha, B. Karthikeyan, and A. Nataraj,” Molecular structure, spectroscopic (FT-IR, FT-Raman), NBO analysis of N,N0-diphenyl-6-piperidin-1-yl-[1,3,5]-triazine-2,4-diamine, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 150 (2015) 476–487.
• S. Sathishkumar, Helen P. Kavitha and S. Arulmurugan, In-silico anti-inflammatory evaluation of some novel tetrazolo and triazolodiazepine derivatives against COX-2 protien,  International Journal of Advanced Chemical Science and Applications, 3(1), 2015
• S. Arulmurugan and Helen P Kavitha, S. Sathishkumar and R. Arulmozhi.       Review on biologically active benzimidazole, Miniriveviews in organic chemistry, 12(1), 178-195, 2015.
• S. Sathishkumar and Helen P. Kavitha, Synthesis, Characterization and Anti-inflammatory Activity of Novel Triazolodiazepine Derivatives, IOSR Journal of Applied Chemistry, 8(1),47-52, 2015.
• A. Silambarasan, Helen P. Kavitha, S. Ponnusamy, M. Navaneethan, Y. Hayakawa, Investigation of photocatalytic behavior of l-aspartic acid stabilized Zn(1−x)MnxS solid solutions on methylene blue Applied Catalysis A: General, 476, 22,1-8, 2014.
• S. Sathish Kumar and Helen P. Kavitha, Synthesis and Biological Applications of Triazole Derivatives-A Review      Mini-Reviews in Organic Chemistry, 10(1), 2013.
• Helen P. Kavitha and S. Arulmurugan     Synthesis, characterization and cytotoxic activity of benzoxazole, benzimidazole, imidazole and tetrazole      Acta pharmaceutica  63(2), 253-264, 2013
• Jasmine P. Vennila, Jhon Thiruvadigal,  Helen P Kavitha,  G. Chakkaravarthi and V. Manivannan, N-[2-(3,4-Dimeth-oxy¬phenyl)eth¬yl]-N-methyl-naphthalene-1-sulfonamide, Acta Crystallogr Sect E, 68(Pt 3): o890, 2012.
• Jasmine P. Vennila, D. Jhon Thiruvadigal,  and Helen P. Kavitha           Antibacterial evaluation of some organic compounds as potential inhibitors for glucosamine-6-phospate synthase            Journal of Pharmacy Research, 5(4), 1963-1966, 2012.
• Helen P. Kavitha and R. Arulmozhi , Synthesis, Characterization and Anti inflammatory Activity of Some New Tetrazoles Derived from Quinazoline-4-one , International Journal of Chemistry, 1-6, 2012.
• S. Arulmurugan, Helen P. Kavitha and S. Sathish Kumar.          Synthesis, characterization and molecular docking studies of some new benzoxazole, benzimidazole, imidazole and tetrazole compounds as potential inhibitors for thymidylate synthase, International Journal of Science and Technology, 1, 1-11 2012.
• Jasmine P. Vennila, Jhon Thiruvadigal, G. E. Theboral Sugi Kamala,  Helen P Kavitha, Chakkaravarthi and V. Manivannan          N-[2-(3,4-Dimeth-oxy¬phen¬yl)eth¬yl]-N-methyl¬benzene-sulfonamide” Acta Crystallogr Sect E Struct Rep Online. 68(Pt 3), o882, 2012.
• Helen P Kavitha, A. Silambarasan, S. Ponnusamy, M. Navaneethan and Y, Hayakawa, Monodispersed synthesis of hierarchical wurtzite ZnS nanostructures and its functional properties” Materials Letters 81, 209-211, 2012.
• Jasmine P. Vennila, Jhon Thiruvadigal, Helen P Kavitha, G. Chakkaravarthi and V. Manivannan, 2-(4-Bromophenyl)-3-(4-hydroxyphenyl)-1,3-thiazolidin-4-one”  Acta Cryst., E67, o1902, 2011.
• Jasmine P. Vennila, D Jhon Thiruvadigal, Helen P Kavitha, G. Chakkaravarthi and V. Manivannan    2,4-Bis(morpholin-4-yl)-6-phenoxy-1,3,5-triazine”  Acta Cryst. E67, o2451, 2011.
• Jasmine P. Vennila, Jhon Thiruvadigal, Helen P Kavitha, G. Chakkaravarthi and V. Manivannan, 2-Chloro-4,6-bis(piperidin-1-yl)-1,3,5-triazine”  Acta Cryst. E67, o312, 2011.
• Helen P. Kavitha, Samiappan Sathish kumar and Ramachandran Balajee           Antimicrobial Activity and Molecular Docking Studies of Some Novel Tetrazolo Diazepine Derivatives, Journal of Pharmacy Research,4(9), 2946-2949, 2011
• Helen P. Kavitha and R. Arulmozhi  Study of Antimicrobial and Analgesic Activities of Novel Tetrazoles Derived from Quinazolin-4-one, Journal of Pharmacy Research , 4(12), 4696-4698, 2011.
• R.Thilagavathy, Helen.P.Kavitha, R.Amrutha and Bathey.R.Venkatraman       Structural parameters, charge distribution and vibrational frequency analysis using theoretical SCF methods, Elixir Comp. Chem. 40, 5514-5516, 2011.
• S. Sathish Kumar, Helen P. Kavitha, S. Arulmurugan  and B. R. Venkatraman, Review on Synthesis of Biologically Active Diazepam Derivatives           Mini-Reviews in Organic Chemistry, 8, 1-17, 2011.
• Jasmine P. Vennila, Jhon Thiruvadigal, Helen P Kavitha, B. Gunasekaran and V. Manivannan, (E)-4-{(4-Bromopenzylidene) amino} phenol, Acta Cryst, E66, O316, 2010.
• Subramaniyan Arulmurugan and Helen P. Kavitha, 2-Methyl-3-{4-[-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one”,     Molbank, M695,1-5, 2010.
• S. Arulmurugan, Helen P. Kavitha and B. R. Venkatraman        Biological Activities of Schiff Base and its Complexes”: A Review,           Rasayan Journal of Chemistry, 3(3), 385-410, 2010.
• R. Thilagavathy, Helen P Kavitha and B. R. venkatraman          Isolation, Characterization and Anti-Inflammatory Property of Thevetia Peruviana     E-journal of Chemistry,7(4), 1584-1590, 2010.
• Subramaniyan  Arulmurugan, Helen P. Kavitha, B. R. Venkatraman, Synthesis, Characterization and Study of antibacterial activity of some novel tetrazole derivatives” ,  Orbital Elec. J. Chem,  2(3), 271-276, 2010.
• With R. Thilagavathi “Synthesis of 3-{4-[4-(benzylideneamino) benzene sulfonyl]-phenyl}-2-phenylquinazoline-4(3H)-one” Molbank, M589, 2009.
• With S.Sathish Kumar “Synthesis of 3-Methyl-1-Morpholin-4-ylmethyl-2,6-Diphenylpiperidin-4-One”, Molbank, M617, 2009.
• With S. Sathish Kumar “6-Methyl-2,7-Diphenyl-1,4-Diazepan-5-One”, Acta Cryst., E65, (o3211), 2009.
• With R. Thilagavathi “2-phenyl-4H-3,1-benzoxazian-4-one”, Acta., Cryst. (E), E65, (o127), 2009.
• With Suneel Manohar Babu “4-Bromo-3-{N[2-(3,4-dimethoxy phenyl)ethyl]-N-methyl-sulfamoyl}-5-methyl benzoic acid mono hydrate”, Acta., Cryst. (E), E65, (o1568), 2009.
• With Suneel Manohar Babu “2,4-Dichloro-N-phenethyl benzene Sulfonamide” , Acta., Cryst. (E), E65, (o921), 2009.
• With Suneel Manohar Babu “N-(5-Bromo-2-Chlorobenzyl)-N-cyclopropylnaphthlene-2-sulfonamide”,  Acta. Cryst. (E), E65, (o1098), 2009.
• With Jasmine P. Vennila “4-nitrophenyl napthalene-1-sulfonate”, Acta Cryst. (E), (o1848), E64, 2008.
• With R. Arulmozhi,”1- Naphthyl-9-HCarbazole-4-Sulphonate”, Acta Cryst., E66, 010208, 2008.
• With T. Nithya “Antibacterial activity of Solanum Trilobatum”, Journal of  Ecotoxicol.Environ. Monit., 14, (237-239), 2004.
• “Synthesis and Antimicrobial activity of1-(9’Acridinyl)-5-substituted phenyl Tetrazoles”, Asian Journal of chemistry, 16, (1191-1192), 2004.
• With S. V. Selva bala “Study of Hypoglysemic Activity of Solanum Xanthocarpum L. on Alloxanised Diabetic Rats”, Adv. Pharmacol Toxicol., 4, (19-24), 2003.
• Helen P. Kavitha “Study of anajesic activity some novel 1-(9’Acridinyl)-5-substituted phenyl tetrazoles”, Indian Journal of Chemical Technology, 9, (361-362), 2002.
• With S.Malliga, “Effect of Soaking the Wood of Emblica officinalis,on Some Water Parameters”, Journal of   Swamy Bot. 15, (89-90), 1998.

Working Papers

• With S. Arulmurugan, “Review on Biologically Active Benzimidazole derivatives”: Mini reviews in organic Chemistry.

Academic Experiences

• Assistant Professor(S. G), SRM University, Ramapuram from Sep 2007 to Jun 2012
• Lecturer, SRM University, Ramapuram from Aug 2004 to Aug 2007
• Senior Lecturer, VRS College, Villupuram from Aug 2002 to May 2004
• Lecturer, VRS College, Villupuram, from Aug 2000 to May 2002
• Lecturer, ADM College for Women, Nagapattinam from July 94 to April 95

Other Professional Experiences

• 4 Scholars have been  awarded Ph.D Degree
• Guiding 3 Ph.D candidates
• Guided 8 M. Phil and 20 M. Sc projects
• Principal Investigator for a pilot project funded by SRM University (completed)
• Co-investigator for a UGC major project (completed)
• Reviewer for  International Journals
• Convenor for the National Conference on New Renaissance in Chemical Research, 2011 and 2015.
• Member Board of Studies –Chemistry,SRM University.
• Doctoral Committee member in Karunya University
• Undertaking consultancy work in the department
• Question paper setter for various universities
• Convenor for many programmes conducted in the campus
• Chief Superintendent for SRM University-Ramapuram campus
• Member in various professional bodies such as MISTE, FICCE and CTA
• Author of five books in chemistry
• Executive council member in Association of Chemistry Teachers, Mumbai

Achievement and Award

• Received Award and cash prize for Research from SRM University from the year 2006-15