AUTHOR OF THIS BLOG

DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER
Jun 292015
 

A novel approach to access ortho iodinated phenols using cyclic hypervalent iodine reagents through palladium(II) catalyzed C–H activation has been developed through weak coordination. The reaction showed excellent regioselectivity, reactivity and good functional group tolerance. A unique mechanism was proposed.

Graphical abstract: Pd(ii) catalyzed ortho C–H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

Pd(II) catalyzed ortho C–H iodination of phenylcarbamates at room temperature using cyclic hypervalent iodine reagents

Xiuyun Sun,a   Xia Yao,a   Chao Zhanga and   Yu Rao*a
*Corresponding authors
aMOE Key Laboratory of Protein Sciences, Department of Pharmacology and Pharmaceutical Sciences, School of Medicine and School of Life Sciences, Tsinghua University, Beijing 100084, China
Chem. Commun., 2015,51, 10014-10017

DOI: 10.1039/C5CC02533H

Rao, Yuyu rao
tsinghua univerisity school of medicines logo

Zhang Chao

 Tsinghua University, Beijing
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