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DR ANTHONY MELVIN CRASTO, WORLDDRUGTRACKER

Renewed focus on dementia checked by drug challenges

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Jul 042014
 

amyloid_precursor

Efforts to target amyloid protein plaques, thought to be responsible for Alzheimer’s disease, have run into trouble © Science Photo Library

The world needs to tackle head-on the market failures undermining dementia research and drug development, UK Prime Minister David Cameron told a summit of world health and finance leaders in London in June. He announced an investigation into how to get medicines to patients earlier, extend patents and facilitate research collaborations, to report this autumn. But just how much difference will these sorts of measures make when scientists are still grappling with exactly what causes different types of dementia?

Renewed focus on dementia checked by drug challenges

‘Ticking time bomb’ of global neurodegenerative disease burden will be difficult to defuse

http://www.rsc.org/chemistryworld/2014/07/asd

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Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

 nanotechnology  Comments Off on Synthesis of water-soluble β-NaYF4 nanocrystals in a green way
Jul 032014
 

Graphical abstract: Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00643G?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-29&utm_source=toc-alert#!divAbstract

Pure β-NaYF4 nanocrystals with a hexagonal phase were synthesized in a novel way at low temperature using sparingly soluble rare-earth salts as precursors and ethanol–water as the solvent. The phase of the products could be controlled by adjusting the water content. An up-converting aqueous colloidal solution and a transparent film were obtained through a simple post-treatment.

 

Synthesis of water-soluble β-NaYF4 nanocrystals in a green way

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*Corresponding authors
aMOE Key Laboratory of Bioinorganic and Synthetic Chemistry/State Key Laboratory of Optoelectronic Materials and Technology, Key Laboratory of Environment and Energy Chemistry of Guangdong Higher Education Institutes, School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou, PR China
E-mail: ceswmm@mail.sysu.edu.cn;
Fax: +86 20 84111038
bDepartment of Chemistry, University of Toronto, 80 St George Street, Toronto, Canada M5S 3H6
E-mail: gozin@chem.utoronto.ca
CrystEngComm, 2014,16, 6526-6529

DOI: 10.1039/C4CE00643G

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Polymorphism of felodipine co-crystals with 4,4′-bipyridine

 polymorph  Comments Off on Polymorphism of felodipine co-crystals with 4,4′-bipyridine
Jul 032014
 

Graphical abstract: Polymorphism of felodipine co-crystals with 4,4′-bipyridine

http://pubs.rsc.org/en/Content/ArticleLanding/2014/CE/C4CE00756E?utm_medium=email&utm_campaign=pub-CE-vol-16-issue-29&utm_source=toc-alert#!divAbstract

The calcium-channel blocking agent felodipine (Fel) forms co-crystals with 4,4′-bipyridine (BP) with 1 : 1 and 2 : 1 molar ratios. The [Fel + BP] (1 : 1) co-crystal exists in two polymorphic forms. Differential scanning calorimetry and solution calorimetry show that form I of the [Fel + BP] (1 : 1) co-crystal is the most thermodynamically stable phase. The difference in the crystal lattice energies between different polymorphs of the co-crystal is found to be comparable with that between the polymorphic forms of pure felodipine. The enthalpies of formation of the co-crystals are small, which indicates that the packing energy gain originates from only weak van der Waals interactions. Analysis of Hirshfeld surfaces of the felodipine molecule shows a similar distribution of intermolecular contacts in the co-crystals and pure felodipine.

Polymorphism of felodipine co-crystals with 4,4′-bipyridine

*Corresponding authors
aInstitution of Russian Academy of Sciences, G.A. Krestov Institute of Solution Chemistry RAS, 153045 Ivanovo, Russia
E-mail: glp@isc-ras.ru;
Fax: +7 4932 336237 ;
Tel: +7 4932 533784
bDepartment of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark
CrystEngComm, 2014,16, 6603-6611

DOI: 10.1039/C4CE00756E

 

 

ANTHONY MELVIN CRASTO

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amcrasto@gmail.com

MOBILE-+91 9323115463
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Biotech Future Looking Rosy BIO Convention: Mood is buoyant at industry’s annual conference

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Jun 302014
 
09226-notw7-biocxd

Rosie the Riveters danced above the flight deck of the U.S.S. Midway at the BIO welcome soiree.
Credit: BIO
High above the flight deck of the U.S.S. Midway, aboard which the Biotechnology Industry Organization (BIO) hosted a welcome party for its annual convention in San Diego last Monday, “Rosie” was written large in red lights. The effect accompanied a dance routine featuring women dressed as Rosie the Riveter, but the reference to the adjective “rosy” was both overt and apropos.
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Growing High-Purity Nanotubes Nanotechnology: 92% of nanotubes generated with a new protocol have identical geometry, conductivity

 Uncategorized  Comments Off on Growing High-Purity Nanotubes Nanotechnology: 92% of nanotubes generated with a new protocol have identical geometry, conductivity
Jun 302014
 
09226-notw5-nanotubescxd

To seed the growth of highly uniform carbon nanotubes (gray), researchers use tungsten-cobalt alloy nanocrystals (yellow and orange), as shown in these side- and top-view illustrations.
Credit: Nanomaterials & Nanostructures Group/Peking
Because of their strength, flexibility, and conductivity, carbon nanotubes might one day feature prominently in devices such as solar cells and miniaturized electronic circuits. Standard methods used to grow the tiny cylinders, however, typically produce a mixture of tubes with varying carbon-atom geometries and electrical properties, making their incorporation into gadgets problematic.
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m-Anisidine, or 3-Methoxyaniline. 间茴香胺 3-氨基茴香醚 NMR

 Uncategorized  Comments Off on m-Anisidine, or 3-Methoxyaniline. 间茴香胺 3-氨基茴香醚 NMR
Jun 282014
 

m-Anisidine, or 3-methoxyaniline.

13C NMR

This 13C spectrum exhibits resonances at the following chemical shifts, and with the multiplicity indicated:

Shift (ppm)
  103.7   CH ORTHO TO OCH3 AND PARA TO AMINO
  100.9   CH ORTHO TO BOTH GPS;SANDWICH
  54.8    OCH3
 

107 .9   CH ORTHO TO AMINO AND PARA TO OCH3

130.2    CH META TO BOTH GPS

148.4   -C-NH2

160.7  -C-OGH3

 

间茴香胺

 

 

1H NMR

 

 

 

间茴香胺

 

MS

间茴香胺

 

IR
间茴香胺
间茴香胺

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