CLICK…….http://www.sciencedirect.com/science/article/pii/S0960894X1400866X
Volume 24, Issue 19, 1 October 2014, Pages 4664–4666
DOI: 10.1016/j.bmcl.2014.08.035
Lisa M. Eubanks, Beverly A. Ellis, Xiaoqing Cai, Joel E. Schlosburg, Kim D. Janda
Abstract
Cocaine abuse remains prevalent worldwide and continues to be a major health concern; nonetheless, there is no effective therapy. Immunopharmacotherapy has emerged as a promising treatment strategy by which anti-cocaine antibodies bind to the drug blunting its effects. Previous passive immunization studies using our human monoclonal antibody, GNCgzk, resulted in protection against cocaine overdose and acute toxicity. To further realize the clinical potential of this antibody, a recombinant IgG form of the antibody has been produced in mammalian cells. This antibody displayed a high binding affinity for cocaine (low nanomolar) in line with the superior attributes of the GNCgzk antibody and reduced cocaine-induced ataxia in a cocaine overdose model.
Keywords
- Cocaine;
- Overdose;
- Immunopharmacotherapy;
- Passive immunization;
- Monoclonal antibody
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