Sep 212014
Continuous flow chemistry: a discovery tool for new chemical reactivity patterns
Jan Hartwig,a Jan B. Metternich,b Nikzad Nikbin,b Andreas Kirschninga and Steven V. Ley*b
*Corresponding authors
aInstitut für Organische Chemie, Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
bInnovative Technology Centre, Department of Chemistry, University of Cambridge, Lensfield Road, UK
E-mail: svl1000@cam.ac.uk
Org. Biomol. Chem., 2014,12, 3611-3615
DOI: 10.1039/C4OB00662C
Continuous flow chemistry as a process intensification tool is well known. However, its ability to enable chemists to perform reactions which are not possible in batch is less well studied or understood. Here we present an example, where a new reactivity pattern and extended reaction scope has been achieved by transferring a reaction from batch mode to flow. This new reactivity can be explained by suppressing back mixing and precise control of temperature in a flow reactor set up.
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