Jun 242014
Chemical Reviews DOI: 10.1021/cr400372p
Exploiting Intrinsic Nanoparticle Toxicity: The Pros and Cons of Nanoparticle-Induced Autophagy in Biomedical Research (Fri, 13 Jun 2014)
>> read more………http://pubs.acs.org/doi/abs/10.1021/cr400372p
Karen Peynshaert †‡, Bella B. Manshian §, Freya Joris †‡, Kevin Braeckmans †‡, Stefaan C. De Smedt *†
, Jo Demeester †, and Stefaan J. Soenen *†§
, Jo Demeester †, and Stefaan J. Soenen *†§†Lab of General Biochemistry and Physical Pharmacy, Faculty of Pharmaceutical Sciences, ‡Centre for Nano- and Biophotonics, and Ghent Research Group on Nanomedicine, Ghent University, B9000 Ghent,Belgium
Ghent Research Group on Nanomedicine, Ghent University, B9000 Ghent,Belgium§ Biomedical MRI Unit/MoSAIC, Department of Imaging and Pathology, Faculty of Medicine, Catholic University of Leuven, B3000 Leuven, Belgium
Chem. Rev., Article ASAP
DOI: 10.1021/cr400372p
Table of Contents
- 1. Introduction
- 2. Nanomedicine
- 2.1. Soft Nanomaterials
- 2.2. Hard Nanomaterials
- 3. Nanotoxicology and the Role of Autophagy
- 3.1. Key Focus Points and Challenges in the Field of Nanotoxicology
- 3.2. Process of Autophagy
- 3.3. Autophagy and Cell Death
- 3.4. How to Study Autophagy
- 3.5. Chemical Modulation of Autophagy
- 4. Nanomaterial-Induced Autophagy
- 4.1. Modulation of autophagy by soft particles
- 4.1.1. Modulation of Autophagy by Liposomes
- 4.1.2. Modulation of Autophagy by Polymeric NPs
- 4.2. Modulation of Autophagy by Hard Nanoparticles
- 4.2.1. Gold Nanoparticles
- 4.2.2. Iron Oxide Nanoparticles
- 4.2.3. Quantum Dots
- 4.2.4. Zinc Oxide Nanoparticles
- 4.2.5. Carbon-Based Nanomaterials
- 4.2.6. Other Hard Nanomaterials
- 4.2.7. Physiological Effects of Nanoparticle-Mediated Autophagy Modulation
- 4.3. Influence of Nanoparticle Characteristics on Autophagy Deregulation
- 4.4. Mechanisms of Autophagy Induction by Nanomaterials
- 4.1. Modulation of autophagy by soft particles
- 5. Dangers of Autophagy Modulation
- 5.1. Autophagy in Neurodegenerative Diseases
- 5.2. Autophagy and Cancer
- 6. Possibilities of Nanomaterial-Induced Autophagy
- 6.1. Selective Destruction of Cancer Cells
- 6.1.1. Selective Autophagy in Cancer Cells
- 6.1.2. Cancer-Specific Induction of Autophagy by Nanomaterials
- 6.1.3. Potential of Nanoparticles in Anticancer Therapy
- 6.2. Autophagy-Mediated Synergistic Effect of Nanoparticles and Chemotherapeutics
- 6.3. Enhanced Tumor Antigen Presentation through Nanoparticle-Mediated Autophagy
- 6.4. Autophagy Induction as a Self-Protection Process against Nanotoxicity
- 6.5. Potential of Nanoparticles for Neuropathological Therapy
- 6.1. Selective Destruction of Cancer Cells
- 7. Conclusions and Outlook
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