1-((3-methoxyphenyl)sulfonyl)piperidine …learn spectroscopy

1-((3-methoxyphenyl)sulfonyl)piperidine (2) is a crystalline white solid

1-((3-Methoxyphenyl)sulfonyl)piperidine: Piperidine,

1-[(3-methoxyphenyl)sulfonyl]-; (2) cas no (173681-65-7)

mp 115-116 °C;

¹H NMR pdf

(400 MHz, DMSO-d₆, 2.50 ppm)

δ: 1.30-1.35 (m, 2 H, N(CH₂CH₂)₂CH₂),

1.47-1.52 (m, 4 H, N(CH₂CH₂)₂CH₂),

2.85 (t, J = 5.2 Hz, 4 H, N(CH₂CH₂)₂CH₂),

3.83 (s, 3 H, OMe),

7.16 (t, J = 2.1 Hz, 1 H, Ar-H),

7.25-7.30 (m, 2 H, Ar-H),

7.55 (t, J = 8.0 Hz, 1 H, Ar-H);

 

¹³C NMR pdf

(100 MHz, DMSO-d₆, 39.5 ppm)

δ: 22.8, 24.7, 46.6, 55.6, 112.3, 118.7, 119.5, 130.5, 136.7, 159.5;

 

IR n_max (film)/cm^-1 2940, 2851, 1597, 1478, 1359, 1340, 1318, 1287, 1241, 1167, 1098, 1040, 931, 856, 724, 688; (principal peaks);

HRMS (FTMS+p-NSF) found m/z 256.1002 [M+H]⁺, C₁₂H₁₈ NO₃S requires m/z 256.1002.

 

Reverse phase HPLC analysis reveals purity >99% (run on an Agilent Zorbax SB-C18, 5 µm, 4.6 x 150 mm column (23 °C) at a flow rate of 1.5 mL/min of 75:25 MeCN:H₂O observed at 210 nm giving a retention time of 1.95 min, 1.0 mg/mL in MeCN).