J. Sarek^1, 2, M. Kvasnica³, M. Vlk^2, 4, M. Urban⁵, P. Dzubak⁶ and M. Hajduch⁶

^[1] Dept. of Org. Chem., IMTM, Faculty of Sciences, Palacky University, Olomouc, Czech Republic

^[2] Betulinines – Chemical group, Stribrna Skalice, Czech Republic

^[3] IOCB, Academy of Sciences, Prague, Czech Republic

^[4] Dept. of Nuclear Chemistry, Faculty of Nuclear Sciences and Physical Engineering, CTU, Prague, Czech Republic

^[5] Dept. of Chem. and Bioch., Univ. of Colorado at Boulder, Colorado, USA

^[6] Lab. of Exp. Medicine, IMTM, Faculty of Medicine and Dentistry, Palacky University and University Hospital in Olomouc, Olomouc, Czech Republic

Figure 1. Vauquelinia corymbosa (Photo: Dr. Carlos Gerardo Velazco Macías)

Figure 2. Gratiola officinalis (photo: http://botanika.wendys.cz);

Figure 3. Platanus acerifolia (photo: www.shutterstock.com);

Figure 4. Ziziphus Mauritiana – bark (photo: http://en.wikipedia.org)

Figure 5. Betulinic acid

Figure 6. Florida cornus – bark (photo: http://en.wikipedia.org);

Figure 7. Betula pendula (photo: www.shutterstock.com)

Figure 8. Vincristine

Figure 9. Betulinic acid

Figure 10. Betulinic acid

Figure 11. Carboxylic acid

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Figure 20. Biotransformation of betulinic acid (1)

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