Dr. Reddy’s Laboratories–An Efficient and Telescopic Process for Valsartan, an Angiotensin II Receptor Blocker

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An efficient, telescopic, and scalable process for an antihypertensive drug substance, valsartan with an overall yield of 58%, and 99.9% purity is described. A simple, and safe process is developed for the recovery of tributyltin chloride from the tributyltin hydroxide, byproduct formed in the tetrazole ring construction, and reused in the synthesis of valsartan.

Dr. Reddy’s Laboratories

Org. Process Res. Dev., 2012, 16 (4), pp 682–686

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